TY - CHAP
T1 - Nanoplasmonic and Microfluidic Devices for Biological Sensing
AU - Perozziello, G.
AU - Giugni, Andrea
AU - Allione, Marco
AU - Torre, Bruno
AU - Das, Gobind
AU - Coluccio, M. L.
AU - Marini, Monica
AU - Tirinato, Luca
AU - Moretti, Manola
AU - Limongi, Tania
AU - Candeloro, P.
AU - Di Fabrizio, Enzo M.
N1 - KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: We acknowledge all contributors that contributed in this work from other institution, in particular the researchers from the previous Nanostructure Division at IIT (Italian Institute of Technology) in Genoa. We thank for the financial support the King Abdullah University of Science and Technology start-up fund and the Italian Minister of Health (projects nos. GR-2010-2320665 and GR-2010-2311677)
PY - 2017/2/17
Y1 - 2017/2/17
N2 - In this chapter we report about recent advances on the development and application of 2D and 3D plasmonic nanostructures used for sensing of biological samples by Raman spectroscopy at unprecedented resolution of analysis. Besides, we explain how the integration of these nanodevices in a microfluidic apparatus can simplify the analysis of biological samples. In the first part we introduce and motivate the convenience of using nanoplasmonic enhancers and Raman spectroscopy for biological sensing, describing the phenomena and the current approaches to fabricate nanoplasmonic structures. In the second part, we explain how specific multi-element devices produce the optimal enhancement of the Raman scattering. We report cases where biological sensing of DNA was performed at few molecules level with nanometer spatial resolutions. Finally, we show an example of microfluidic device integrating plasmonic nanodevices to sort and drive biological samples, like living cells, towards the optical probe in order to obtain optimal conditions of analysis.
AB - In this chapter we report about recent advances on the development and application of 2D and 3D plasmonic nanostructures used for sensing of biological samples by Raman spectroscopy at unprecedented resolution of analysis. Besides, we explain how the integration of these nanodevices in a microfluidic apparatus can simplify the analysis of biological samples. In the first part we introduce and motivate the convenience of using nanoplasmonic enhancers and Raman spectroscopy for biological sensing, describing the phenomena and the current approaches to fabricate nanoplasmonic structures. In the second part, we explain how specific multi-element devices produce the optimal enhancement of the Raman scattering. We report cases where biological sensing of DNA was performed at few molecules level with nanometer spatial resolutions. Finally, we show an example of microfluidic device integrating plasmonic nanodevices to sort and drive biological samples, like living cells, towards the optical probe in order to obtain optimal conditions of analysis.
UR - http://hdl.handle.net/10754/623189
UR - http://link.springer.com/chapter/10.1007/978-94-024-0850-8_12
UR - http://www.scopus.com/inward/record.url?scp=85014110177&partnerID=8YFLogxK
U2 - 10.1007/978-94-024-0850-8_12
DO - 10.1007/978-94-024-0850-8_12
M3 - Chapter
SN - 9789402408485
SP - 247
EP - 274
BT - NATO Science for Peace and Security Series B: Physics and Biophysics
PB - Springer Nature
ER -