Nanotopographic carbon nanotube thin-film substrate freezes lateral motion of secretory vesicles

Jing Zhang; Dongliang Fu; Mary B. Chan-Park; Lain Jong Li; Peng Chen

doi:10.1002/adma.200801586

Nanotopographic carbon nanotube thin-film substrate freezes lateral motion of secretory vesicles

Jing Zhang^*, Dongliang Fu, Mary B. Chan-Park, Lain Jong Li, Peng Chen

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

A study was conducted to examine the effects of a nanotopographic CNT substrate on the motion of secretory vesicles in neuronendocrine PC12 cells. It was observed that the nanotopography of CNT networks can affect specific cellular activity and vesicle-motion dynamics of all secretory cells including neurons, endocrine cells, osteoblasts, and immune cells. CNT substrates used for this study were coated with an adhesion-promoting polypeptide (poly(l-lysine)) to directly interact with cell membrane and adhesion proteins. It was found during the study that the cell morphology, growth, proliferation, differentiation, vesicle size and number, nature of vesicle motion, vesicle vertical trafficking, and vesicle dwell time remained unaffected by CNT substrates. The study provided a significant insight for understanding the biocompatibility between live cells and nanostructures.

Original language	English (US)
Pages (from-to)	790-793
Number of pages	4
Journal	Advanced Materials
Volume	21
Issue number	7
DOIs	https://doi.org/10.1002/adma.200801586
State	Published - Feb 16 2009
Externally published	Yes

ASJC Scopus subject areas

General Materials Science
Mechanics of Materials
Mechanical Engineering

Access to Document

10.1002/adma.200801586

Cite this

@article{becd9f8ac5fd48569e416b0985a8927b,

title = "Nanotopographic carbon nanotube thin-film substrate freezes lateral motion of secretory vesicles",

abstract = "A study was conducted to examine the effects of a nanotopographic CNT substrate on the motion of secretory vesicles in neuronendocrine PC12 cells. It was observed that the nanotopography of CNT networks can affect specific cellular activity and vesicle-motion dynamics of all secretory cells including neurons, endocrine cells, osteoblasts, and immune cells. CNT substrates used for this study were coated with an adhesion-promoting polypeptide (poly(l-lysine)) to directly interact with cell membrane and adhesion proteins. It was found during the study that the cell morphology, growth, proliferation, differentiation, vesicle size and number, nature of vesicle motion, vesicle vertical trafficking, and vesicle dwell time remained unaffected by CNT substrates. The study provided a significant insight for understanding the biocompatibility between live cells and nanostructures.",

author = "Jing Zhang and Dongliang Fu and Chan-Park, {Mary B.} and Li, {Lain Jong} and Peng Chen",

year = "2009",

month = feb,

day = "16",

doi = "10.1002/adma.200801586",

language = "English (US)",

volume = "21",

pages = "790--793",

journal = "Advanced Materials",

issn = "0935-9648",

publisher = "WILEY-V C H VERLAG GMBH",

number = "7",

}

TY - JOUR

T1 - Nanotopographic carbon nanotube thin-film substrate freezes lateral motion of secretory vesicles

AU - Zhang, Jing

AU - Fu, Dongliang

AU - Chan-Park, Mary B.

AU - Li, Lain Jong

AU - Chen, Peng

PY - 2009/2/16

Y1 - 2009/2/16

N2 - A study was conducted to examine the effects of a nanotopographic CNT substrate on the motion of secretory vesicles in neuronendocrine PC12 cells. It was observed that the nanotopography of CNT networks can affect specific cellular activity and vesicle-motion dynamics of all secretory cells including neurons, endocrine cells, osteoblasts, and immune cells. CNT substrates used for this study were coated with an adhesion-promoting polypeptide (poly(l-lysine)) to directly interact with cell membrane and adhesion proteins. It was found during the study that the cell morphology, growth, proliferation, differentiation, vesicle size and number, nature of vesicle motion, vesicle vertical trafficking, and vesicle dwell time remained unaffected by CNT substrates. The study provided a significant insight for understanding the biocompatibility between live cells and nanostructures.

AB - A study was conducted to examine the effects of a nanotopographic CNT substrate on the motion of secretory vesicles in neuronendocrine PC12 cells. It was observed that the nanotopography of CNT networks can affect specific cellular activity and vesicle-motion dynamics of all secretory cells including neurons, endocrine cells, osteoblasts, and immune cells. CNT substrates used for this study were coated with an adhesion-promoting polypeptide (poly(l-lysine)) to directly interact with cell membrane and adhesion proteins. It was found during the study that the cell morphology, growth, proliferation, differentiation, vesicle size and number, nature of vesicle motion, vesicle vertical trafficking, and vesicle dwell time remained unaffected by CNT substrates. The study provided a significant insight for understanding the biocompatibility between live cells and nanostructures.

UR - http://www.scopus.com/inward/record.url?scp=60349102968&partnerID=8YFLogxK

U2 - 10.1002/adma.200801586

DO - 10.1002/adma.200801586

M3 - Article

AN - SCOPUS:60349102968

SN - 0935-9648

VL - 21

SP - 790

EP - 793

JO - Advanced Materials

JF - Advanced Materials

IS - 7

ER -

Nanotopographic carbon nanotube thin-film substrate freezes lateral motion of secretory vesicles

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this