TY - JOUR
T1 - Natural Oils Enhance the Topical Delivery of Ketoconazole by Nanoemulgel for Fungal Infections
AU - Ahmad, Irfan
AU - Farheen, Ms
AU - Kukreti, Ashish
AU - Afzal, Obaid
AU - Akhter, Md Habban
AU - Chitme, Havagiray
AU - Visht, Sharad
AU - Altamimi, Abdulmalik Saleh Alfawaz
AU - Alossaimi, Manal A.
AU - Alsulami, Ebtisam R.
AU - Jaremko, Mariusz
AU - Emwas, Abdul-Hamid M.
N1 - KAUST Repository Item: Exported on 2023-07-31
Acknowledgements: The authors express their gratitude to the Deanship of Scientific Research at King Khalid University for funding this work through the Small Research Group Project under grant no. RGP.01/370/43.
PY - 2023/7/26
Y1 - 2023/7/26
N2 - Nanoemulgel (NEG) pharmaceutical formulations are gaining popularity because of their ability to serve both as a nanoemulsion and as a gel. These products are well-known for their ease of use, spreadability, controlled release, and ability to hydrate dry skin. Natural essential oils have been shown to promote the cutaneous permeability of topical formulations, enhancing medication safety and efficacy. Herein, we developed NEG for the enhanced permeation of ketoconazole against candidiasis using clove oil (clove-oil–NEG) or eucalyptus oil (eucalyptus-oil–NEG), using the gelling agents carbopol 943 and hydroxypropyl methylcellulose (HPMC). We tested various excipients to increase the solubility of ketoconazole and formulate a nanoemulsion (NE). We measured the NE droplet particle size, shape, entrapment efficiency, and drug release. Furthermore, the physicochemical properties of the optimized nanoemulsion formulation were characterized by techniques such as Fourier transform infrared (FT-IR) spectroscopy and X-ray diffraction (XRD) analysis. The NEs were loaded into gels to form NEGs. NEGs were characterized for drug content, homogeneity, rheology, spreadability, and antifungal activity against Candida albicans, both in vitro and in vivo. Optimized ketoconazole NEG preparations consisted of either 15% clove oil or 20% eucalyptus oil. Droplet sizes in the optimized NEs were
AB - Nanoemulgel (NEG) pharmaceutical formulations are gaining popularity because of their ability to serve both as a nanoemulsion and as a gel. These products are well-known for their ease of use, spreadability, controlled release, and ability to hydrate dry skin. Natural essential oils have been shown to promote the cutaneous permeability of topical formulations, enhancing medication safety and efficacy. Herein, we developed NEG for the enhanced permeation of ketoconazole against candidiasis using clove oil (clove-oil–NEG) or eucalyptus oil (eucalyptus-oil–NEG), using the gelling agents carbopol 943 and hydroxypropyl methylcellulose (HPMC). We tested various excipients to increase the solubility of ketoconazole and formulate a nanoemulsion (NE). We measured the NE droplet particle size, shape, entrapment efficiency, and drug release. Furthermore, the physicochemical properties of the optimized nanoemulsion formulation were characterized by techniques such as Fourier transform infrared (FT-IR) spectroscopy and X-ray diffraction (XRD) analysis. The NEs were loaded into gels to form NEGs. NEGs were characterized for drug content, homogeneity, rheology, spreadability, and antifungal activity against Candida albicans, both in vitro and in vivo. Optimized ketoconazole NEG preparations consisted of either 15% clove oil or 20% eucalyptus oil. Droplet sizes in the optimized NEs were
UR - http://hdl.handle.net/10754/693332
UR - https://pubs.acs.org/doi/10.1021/acsomega.3c01571
U2 - 10.1021/acsomega.3c01571
DO - 10.1021/acsomega.3c01571
M3 - Article
C2 - 37576685
SN - 2470-1343
JO - ACS OMEGA
JF - ACS OMEGA
ER -