TY - JOUR
T1 - Neural Functions Play Different Roles in Triple Negative Breast Cancer (TNBC) and non-TNBC
AU - Tan, Renbo
AU - Li, Haoyang
AU - Huang, Zhenyu
AU - Zhou, Yi
AU - Tao, Mingxin
AU - Gao, Xin
AU - Xu, Ying
N1 - KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: The authors thank Professor Sha Cao of Indiana University Biostatistics Department for the advice regarding data analytics. The senior author thanks the financial support from both Georgia Research Alliance and the China-Japan Union Hospital of Jilin University.
PY - 2020/2/20
Y1 - 2020/2/20
N2 - Triple negative breast cancer (TNBC) represents the most malignant subtype of breast cancer, and yet our understanding about its unique biology remains elusive. We have conducted a comparative computational analysis of transcriptomic data of TNBC and non-TNBC (NTNBC) tissue samples from the TCGA database, focused on genes involved in neural functions. Our main discoveries are: (1) while both subtypes involve neural functions, TNBC has substantially more up-regulated neural genes than NTNBC, suggesting that TNBC is more complex than NTNBC; (2) non-neural functions related to cell-microenvironment interactions and intracellular damage processing are key inducers of the neural genes in both TNBC and NTNBC, but the inducer-responder relationships are different in the two cancer subtypes; (3) key neural functions such as neural crest formation are predicted to enhance adaptive immunity in TNBC while glia development, along with a few other neural functions, induce both innate and adaptive immunity in NTNBC. These results reveal key differences in the biology between the two cancer subtypes, particularly in terms of the roles that neural functions play. Our findings may open new doors for further investigation of the distinct biology of TNBC vs. NTNBC.
AB - Triple negative breast cancer (TNBC) represents the most malignant subtype of breast cancer, and yet our understanding about its unique biology remains elusive. We have conducted a comparative computational analysis of transcriptomic data of TNBC and non-TNBC (NTNBC) tissue samples from the TCGA database, focused on genes involved in neural functions. Our main discoveries are: (1) while both subtypes involve neural functions, TNBC has substantially more up-regulated neural genes than NTNBC, suggesting that TNBC is more complex than NTNBC; (2) non-neural functions related to cell-microenvironment interactions and intracellular damage processing are key inducers of the neural genes in both TNBC and NTNBC, but the inducer-responder relationships are different in the two cancer subtypes; (3) key neural functions such as neural crest formation are predicted to enhance adaptive immunity in TNBC while glia development, along with a few other neural functions, induce both innate and adaptive immunity in NTNBC. These results reveal key differences in the biology between the two cancer subtypes, particularly in terms of the roles that neural functions play. Our findings may open new doors for further investigation of the distinct biology of TNBC vs. NTNBC.
UR - http://hdl.handle.net/10754/661614
UR - http://www.nature.com/articles/s41598-020-60030-5
UR - http://www.scopus.com/inward/record.url?scp=85079769333&partnerID=8YFLogxK
U2 - 10.1038/s41598-020-60030-5
DO - 10.1038/s41598-020-60030-5
M3 - Article
C2 - 32080331
SN - 2045-2322
VL - 10
JO - Scientific Reports
JF - Scientific Reports
IS - 1
ER -