New Series of Zaxinone Mimics (MiZax) for Fundamental and Applied Research

Muhammad Jamil, Pei Yu Lin, Lamis Berqdar, Jian You Wang, Ikuo Takahashi, Tsuyoshi Ota, Noor Alhammad, Guan Ting Erica Chen, Tadao Asami, Salim Al-Babili*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The apocarotenoid zaxinone is a recently discovered regulatory metabolite required for proper rice growth and development. In addition, zaxinone and its two mimics (MiZax3 and MiZax5) were shown to have a remarkable growth-promoting activity on crops and a capability to reduce infestation by the root parasitic plant Striga through decreasing strigolactone (SL) production, suggesting their potential for application in agriculture and horticulture. In the present study, we developed a new series of MiZax via structural modification of the two potent zaxinone mimics (MiZax3 and MiZax5) and evaluated their effect on plant growth and Striga infestation. In general, the structural modifications to MiZax3 and MiZax5 did not additionally improve their overall performance but caused an increase in certain activities. In conclusion, MiZax5 and especially MiZax3 remain the likely most efficient zaxinone mimics for controlling Striga infestation.

Original languageEnglish (US)
Article number1206
JournalBiomolecules
Volume13
Issue number8
DOIs
StatePublished - Aug 2023

Keywords

  • mimics of zaxinone (MiZax)
  • plant growth regulator
  • Striga hermonthica
  • strigolactones
  • zaxinone

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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