NFIX - One gene, two knockouts, multiple effects

Vladimir Pekarik, Juan Carlos Izpisua Belmonte

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


A previous knockout of the transcription factor gene nuclear factor IX (NFIX) in mice produced impaired development of the corpus callosum and severe skeletal defects. A recent paper in BMC Developmental Biology reports an apparently similar NFIX knockout that produced marked differences in phenotype, raising intriguing general questions about the possible causes of such differences in mouse knockouts.

Original languageEnglish (US)
Article number29
JournalJournal of Biology
Issue number8
StatePublished - 2008
Externally publishedYes

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology
  • General Agricultural and Biological Sciences


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