Nickel-Catalyzed C sp2 –C sp3 Cross-Coupling via C–O Bond Activation

Lin Guo, Chien-Chi Hsiao, Huifeng Yue, Xiangqian Liu, Magnus Rueping

Research output: Contribution to journalArticlepeer-review

76 Scopus citations


A new and efficient nickel-catalyzed alkylation of CAr-O electrophiles with B-alkyl-9-BBNs is described. The transformation is characterized by its functional group tolerance and provides a practical and versatile access to various Csp2-Csp3 bonds through Csp2-O substitution, without the restriction of β-hydride elimination. Moreover, the advantage of the newly developed method was demonstrated in a selective and sequential C-O bond activation process. © 2016 American Chemical Society.
Original languageEnglish (US)
Pages (from-to)4438-4442
Number of pages5
JournalACS Catalysis
Issue number7
StatePublished - Jun 13 2016


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