TY - JOUR
T1 - Non-Classical C–H···X Hydrogen Bonding and Its Role in Asymmetric Organocatalysis
AU - Ajitha, Manjaly John
AU - Huang, Kuo-Wei
N1 - KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: This work is supported by King Abdullah University of Science and Technology (KAUST).
PY - 2016/8/17
Y1 - 2016/8/17
N2 - Non-classical hydrogen bonds (NCHBs) have attracted significant interest in the past decade particularly because of their important role in asymmetric catalytic systems. These weak interactions (< 4 kcal/mol) offer much flexibility in the preorganization of molecular entities required to achieve high enantioselectivity. Herein, we review some recent important organocatalytic asymmetric reactions where a NCHB serves as a critical factor in determining the stereoselectivity.
AB - Non-classical hydrogen bonds (NCHBs) have attracted significant interest in the past decade particularly because of their important role in asymmetric catalytic systems. These weak interactions (< 4 kcal/mol) offer much flexibility in the preorganization of molecular entities required to achieve high enantioselectivity. Herein, we review some recent important organocatalytic asymmetric reactions where a NCHB serves as a critical factor in determining the stereoselectivity.
UR - http://hdl.handle.net/10754/622438
UR - https://www.thieme-connect.de/DOI/DOI?10.1055/s-0035-1562475
UR - http://www.scopus.com/inward/record.url?scp=84983071825&partnerID=8YFLogxK
U2 - 10.1055/s-0035-1562475
DO - 10.1055/s-0035-1562475
M3 - Article
SN - 0039-7881
VL - 48
SP - 3449
EP - 3458
JO - Synthesis
JF - Synthesis
IS - 20
ER -