Non-Classical C–H···X Hydrogen Bonding and Its Role in Asymmetric Organocatalysis

Manjaly John Ajitha, Kuo-Wei Huang

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


Non-classical hydrogen bonds (NCHBs) have attracted significant interest in the past decade particularly because of their important role in asymmetric catalytic systems. These weak interactions (< 4 kcal/mol) offer much flexibility in the preorganization of molecular entities required to achieve high enantioselectivity. Herein, we review some recent important organocatalytic asymmetric reactions where a NCHB serves as a critical factor in determining the stereoselectivity.
Original languageEnglish (US)
Pages (from-to)3449-3458
Number of pages10
Issue number20
StatePublished - Aug 17 2016


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