Nonlinear electro-mechanobiological behavior of cell membrane during electroporation

Peigang Deng; Yi-Kuen Lee; Ran Lin; Tong-Yi Zhang

doi:10.1063/1.4739940

Nonlinear electro-mechanobiological behavior of cell membrane during electroporation

Peigang Deng, Yi-Kuen Lee, Ran Lin, Tong-Yi Zhang

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

A nonlinear electroporation (EP) model is proposed to study the electro-mechanobiological behavior of cell membrane during EP, by taking the nonlinear large deformation of the membrane into account. The proposed model predicts the critical transmembrane potential and the activation energy for EP, the equilibrium pore size, and the resealing process of the pore. Single-cell EP experiments using a micro EP chip were conducted on chicken red blood cells at different temperatures to determine the activation energy and the critical transmembrane potential for EP. The experimental results are in good agreement with the theoretical predictions. © 2012 American Institute of Physics.

Original language	English (US)
Pages (from-to)	053702
Journal	Applied Physics Letters
Volume	101
Issue number	5
DOIs	https://doi.org/10.1063/1.4739940
State	Published - Jul 30 2012
Externally published	Yes

Access to Document

10.1063/1.4739940

Cite this

@article{d0b895ce0d754638b23c49161bf91e26,

title = "Nonlinear electro-mechanobiological behavior of cell membrane during electroporation",

abstract = "A nonlinear electroporation (EP) model is proposed to study the electro-mechanobiological behavior of cell membrane during EP, by taking the nonlinear large deformation of the membrane into account. The proposed model predicts the critical transmembrane potential and the activation energy for EP, the equilibrium pore size, and the resealing process of the pore. Single-cell EP experiments using a micro EP chip were conducted on chicken red blood cells at different temperatures to determine the activation energy and the critical transmembrane potential for EP. The experimental results are in good agreement with the theoretical predictions. {\textcopyright} 2012 American Institute of Physics.",

author = "Peigang Deng and Yi-Kuen Lee and Ran Lin and Tong-Yi Zhang",

note = "KAUST Repository Item: Exported on 2020-10-01 Acknowledged KAUST grant number(s): SA-C0040/UK-C0016 Acknowledgements: This research was partially supported by a Hong Kong RGC grant (No. 615907) and by an award from the King Abdullah University of Science and Technology (KAUST Award No. SA-C0040/UK-C0016). This publication acknowledges KAUST support, but has no KAUST affiliated authors.",

year = "2012",

month = jul,

day = "30",

doi = "10.1063/1.4739940",

language = "English (US)",

volume = "101",

pages = "053702",

journal = "Applied Physics Letters",

issn = "0003-6951",

publisher = "American Institute of Physics",

number = "5",

}

TY - JOUR

T1 - Nonlinear electro-mechanobiological behavior of cell membrane during electroporation

AU - Deng, Peigang

AU - Lee, Yi-Kuen

AU - Lin, Ran

AU - Zhang, Tong-Yi

N1 - KAUST Repository Item: Exported on 2020-10-01 Acknowledged KAUST grant number(s): SA-C0040/UK-C0016 Acknowledgements: This research was partially supported by a Hong Kong RGC grant (No. 615907) and by an award from the King Abdullah University of Science and Technology (KAUST Award No. SA-C0040/UK-C0016). This publication acknowledges KAUST support, but has no KAUST affiliated authors.

PY - 2012/7/30

Y1 - 2012/7/30

N2 - A nonlinear electroporation (EP) model is proposed to study the electro-mechanobiological behavior of cell membrane during EP, by taking the nonlinear large deformation of the membrane into account. The proposed model predicts the critical transmembrane potential and the activation energy for EP, the equilibrium pore size, and the resealing process of the pore. Single-cell EP experiments using a micro EP chip were conducted on chicken red blood cells at different temperatures to determine the activation energy and the critical transmembrane potential for EP. The experimental results are in good agreement with the theoretical predictions. © 2012 American Institute of Physics.

AB - A nonlinear electroporation (EP) model is proposed to study the electro-mechanobiological behavior of cell membrane during EP, by taking the nonlinear large deformation of the membrane into account. The proposed model predicts the critical transmembrane potential and the activation energy for EP, the equilibrium pore size, and the resealing process of the pore. Single-cell EP experiments using a micro EP chip were conducted on chicken red blood cells at different temperatures to determine the activation energy and the critical transmembrane potential for EP. The experimental results are in good agreement with the theoretical predictions. © 2012 American Institute of Physics.

UR - http://hdl.handle.net/10754/598990

UR - http://aip.scitation.org/doi/10.1063/1.4739940

UR - http://www.scopus.com/inward/record.url?scp=84864646975&partnerID=8YFLogxK

U2 - 10.1063/1.4739940

DO - 10.1063/1.4739940

M3 - Article

SN - 0003-6951

VL - 101

SP - 053702

JO - Applied Physics Letters

JF - Applied Physics Letters

IS - 5

ER -

Nonlinear electro-mechanobiological behavior of cell membrane during electroporation

Abstract

Access to Document

Other files and links

Fingerprint

Cite this