Novel PEGylated pH-sensitive polymeric hollow microspheres

Panayiotis Bilalis; Nikos Boukos; George C. Kordas

doi:10.1016/j.matlet.2011.09.062

Novel PEGylated pH-sensitive polymeric hollow microspheres

Panayiotis Bilalis, Nikos Boukos, George C. Kordas^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Novel PEGylated pH-sensitive poly[methacrylic acid-co-poly(ethylene glycol) methyl ether methacrylate] [P(MAA-co-PEGMA)] hollow microspheres were synthesized by a two-stage distillation precipitation polymerization. PMAA@P(MAA-co-PEGMA) core shell microspheres were synthesized by the second-stage polymerization of MAA and PEGMA, using the N,N′- methylenebisacrylamide (MBAAm) as crosslinker in the presence of non-crosslinked PMAA microspheres. The cavity was formed by selective removal of PMAA core in ethanol. The resulted PEGylated hollow microspheres were characterized with Transmission Electron Microscopy (TEM), Scanning Electron Microscopy (SEM) and Fourier Transform Infrared Spectroscopy (FT-IR). The shrink and swelling behavior under different pH was studied by Dynamic Light Scattering (DLS).

Original language	English (US)
Pages (from-to)	180-183
Number of pages	4
Journal	Materials Letters
Volume	67
Issue number	1
DOIs	https://doi.org/10.1016/j.matlet.2011.09.062
State	Published - Jan 15 2012
Externally published	Yes

Keywords

Hollow microspheres
PEG
PEGylated
PMAA
Polymer
pH-sensitive

ASJC Scopus subject areas

General Materials Science
Condensed Matter Physics
Mechanics of Materials
Mechanical Engineering

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10.1016/j.matlet.2011.09.062

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title = "Novel PEGylated pH-sensitive polymeric hollow microspheres",

abstract = "Novel PEGylated pH-sensitive poly[methacrylic acid-co-poly(ethylene glycol) methyl ether methacrylate] [P(MAA-co-PEGMA)] hollow microspheres were synthesized by a two-stage distillation precipitation polymerization. PMAA@P(MAA-co-PEGMA) core shell microspheres were synthesized by the second-stage polymerization of MAA and PEGMA, using the N,N′- methylenebisacrylamide (MBAAm) as crosslinker in the presence of non-crosslinked PMAA microspheres. The cavity was formed by selective removal of PMAA core in ethanol. The resulted PEGylated hollow microspheres were characterized with Transmission Electron Microscopy (TEM), Scanning Electron Microscopy (SEM) and Fourier Transform Infrared Spectroscopy (FT-IR). The shrink and swelling behavior under different pH was studied by Dynamic Light Scattering (DLS).",

keywords = "Hollow microspheres, PEG, PEGylated, PMAA, Polymer, pH-sensitive",

author = "Panayiotis Bilalis and Nikos Boukos and Kordas, {George C.}",

note = "Funding Information: We thank the European Research Council (ERC) for financial support of this work under the “IDEAS” project called “A Novel Nano-container drug carrier for targeted treatment of prostate cancer” with the acronym NANOTHERAPY and the reference number 232959 . ",

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AU - Boukos, Nikos

AU - Kordas, George C.

N1 - Funding Information: We thank the European Research Council (ERC) for financial support of this work under the “IDEAS” project called “A Novel Nano-container drug carrier for targeted treatment of prostate cancer” with the acronym NANOTHERAPY and the reference number 232959 .

PY - 2012/1/15

Y1 - 2012/1/15

N2 - Novel PEGylated pH-sensitive poly[methacrylic acid-co-poly(ethylene glycol) methyl ether methacrylate] [P(MAA-co-PEGMA)] hollow microspheres were synthesized by a two-stage distillation precipitation polymerization. PMAA@P(MAA-co-PEGMA) core shell microspheres were synthesized by the second-stage polymerization of MAA and PEGMA, using the N,N′- methylenebisacrylamide (MBAAm) as crosslinker in the presence of non-crosslinked PMAA microspheres. The cavity was formed by selective removal of PMAA core in ethanol. The resulted PEGylated hollow microspheres were characterized with Transmission Electron Microscopy (TEM), Scanning Electron Microscopy (SEM) and Fourier Transform Infrared Spectroscopy (FT-IR). The shrink and swelling behavior under different pH was studied by Dynamic Light Scattering (DLS).

AB - Novel PEGylated pH-sensitive poly[methacrylic acid-co-poly(ethylene glycol) methyl ether methacrylate] [P(MAA-co-PEGMA)] hollow microspheres were synthesized by a two-stage distillation precipitation polymerization. PMAA@P(MAA-co-PEGMA) core shell microspheres were synthesized by the second-stage polymerization of MAA and PEGMA, using the N,N′- methylenebisacrylamide (MBAAm) as crosslinker in the presence of non-crosslinked PMAA microspheres. The cavity was formed by selective removal of PMAA core in ethanol. The resulted PEGylated hollow microspheres were characterized with Transmission Electron Microscopy (TEM), Scanning Electron Microscopy (SEM) and Fourier Transform Infrared Spectroscopy (FT-IR). The shrink and swelling behavior under different pH was studied by Dynamic Light Scattering (DLS).

KW - Hollow microspheres

KW - PEG

KW - PEGylated

KW - PMAA

KW - Polymer

KW - pH-sensitive

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JO - Materials Letters

JF - Materials Letters

IS - 1

ER -

Novel PEGylated pH-sensitive polymeric hollow microspheres

Abstract

Keywords

ASJC Scopus subject areas

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