TY - JOUR
T1 - Omega hydroxylated JA-Ile is an endogenous bioactive jasmonate that signals through the canonical jasmonate signaling pathway
AU - Jimenez-Aleman, Guillermo H.
AU - Almeida-Trapp, Marilia
AU - Fernandez-Barbero, Gemma
AU - Gimenez-Ibanez, Selena
AU - Reichelt, Michael
AU - Vadassery, Jyothilakshmi
AU - Mithoefer, Axel
AU - Caballero, Julio
AU - Boland, Wilhelm
AU - Solano, Roberto
N1 - KAUST Repository Item: Exported on 2021-07-13
Acknowledgements: Fellowships granted by the DFG to G.H.J.A. (Grant JI 241/2-1) and by CAPES-Humboldt to M.A.T. (Grant 99999.007611/2015-03) are gratefully acknowledged. Work in R. Solano's lab was funded by the Spanish Ministry for Science and Innovation grant BIO2016-77216-R (MINECO/FEDER). The authors thank the Max Planck Society for funding. We thank Andrea Lehr for technical assistance and the MPI-CE greenhouse team for cultivation of plants. The authors thank Prof. T. Heitz for providing the b1b3c1 mutant.
PY - 2019
Y1 - 2019
N2 - Jasmonates are fatty acid derivatives that control several plant processes including growth, development and defense. Despite the chemical diversity of jasmonates, only jasmonoyl-L-isoleucine (JA-Ile) has been clearly characterized as the endogenous ligand of the jasmonate co-receptors (COI1-JAZs) in higher plants. Currently, it is accepted that ω-hydroxylation of JA-Ile leads to inactivation of the molecule. This study shows that ω-hydroxylated JA-Ile (12-OH-JA-Ile) retains bioactivity and signals through the canonical JA-pathway. The results suggest that 12-OH-JA-Ile differentially activates a subset of JA-Ile co-receptors that may control and/or modulate particular jasmonate dependent responses. It is proposed that after a strong immune response mediated by JA-Ile, the ω-hydroxylated form modulates JA-Ile activated processes thereby improving plant resilience.
AB - Jasmonates are fatty acid derivatives that control several plant processes including growth, development and defense. Despite the chemical diversity of jasmonates, only jasmonoyl-L-isoleucine (JA-Ile) has been clearly characterized as the endogenous ligand of the jasmonate co-receptors (COI1-JAZs) in higher plants. Currently, it is accepted that ω-hydroxylation of JA-Ile leads to inactivation of the molecule. This study shows that ω-hydroxylated JA-Ile (12-OH-JA-Ile) retains bioactivity and signals through the canonical JA-pathway. The results suggest that 12-OH-JA-Ile differentially activates a subset of JA-Ile co-receptors that may control and/or modulate particular jasmonate dependent responses. It is proposed that after a strong immune response mediated by JA-Ile, the ω-hydroxylated form modulates JA-Ile activated processes thereby improving plant resilience.
UR - http://hdl.handle.net/10754/670128
UR - https://linkinghub.elsevier.com/retrieve/pii/S138819811930160X
UR - http://www.scopus.com/inward/record.url?scp=85071839680&partnerID=8YFLogxK
U2 - 10.1016/j.bbalip.2019.158520
DO - 10.1016/j.bbalip.2019.158520
M3 - Article
SN - 1879-2618
VL - 1864
SP - 158520
JO - BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
JF - BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
IS - 12
ER -