One-pot facile synthesis of PEGylated Au nanoparticles in an aqueous media

Sevket Tolga Camli, Fatih Buyukserin, Cafer T. Yavuz, Mustafa Selman Yavuz

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


We describe a facile protocol for the synthesis of PEGylated Au nanoparticles by simply mixing aqueous solutions of HAuCl 4 and oligo(ethylene glycol) ethyl ether methacrylate. This method was applied to generate uniform multiply-twinned Au nanostructures of ∼21 nm in diameter with high yields. Our proposed mechanism indicates that the generation of primary alcohol intermediates from the nucleophilic addition reaction of water (nucleophile) with AuIII-vinyl complex is responsible for the reduction of gold ions. This protocol was also used to synthesize Ag nanoparticles and small aggregates of Pd nanoparticles. Due to the exclusion of sophisticated synthesis of PEG containing stabilizers, additional surfactants, or reducing agents, this approach provides a remarkably simple, versatile, and environmentally benign protocol to prepare PEGylated noble-metal nanocrystals. A comparative BSA adsorption study proved the lack of non-specific binding, a common obstacle in designing biocompatible nanoparticles. © 2012 Elsevier B.V. All rights reserved.
Original languageEnglish (US)
Pages (from-to)1153-1159
Number of pages7
JournalMaterials Chemistry and Physics
Issue number2-3
StatePublished - Jun 15 2012
Externally publishedYes

ASJC Scopus subject areas

  • General Materials Science
  • Condensed Matter Physics


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