A facile one-pot synthesis of N-(α-peroxy)indole and N-(α-peroxy)carbazole has been developed using metal-free, organo-acid-catalyzed three-component condensation reactions of indole/carbazole, aldehyde, and peroxide. Based on the reaction discovered, a new synthetic proposal for Fumitremorgin A and Verruculogen is introduced. Such a protocol could be easily handled and scaled up in an open atmosphere with a wide substrate scope, enabling the construction of a new molecule library.
|Original language||English (US)|
|Number of pages||4|
|State||Published - Nov 6 2015|
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CCDC 1438644: Experimental Crystal Structure Determination : 9-(1-(t-Butylperoxy)heptyl)-9H-carbazole
Wang, X. (Creator), Pan, Y. (Creator), Huang, K. (Creator) & Lai, Z. (Creator), Cambridge Crystallographic Data Centre, Nov 24 2015
DOI: 10.5517/cc1k90wr, http://hdl.handle.net/10754/624487