Abstract
To avoid the existing limitations of the PCA process for the precipitation of proteins and polar polymers a new approach based on the use of water to modify the phase behaviour of the system DMSO-CO2 was developed. The addition of water to the DMSO displaces the mixture critical pressure of the solution-CO2 system to higher pressures and produces a new operating region in which the PCA process can be carried out. Following this approach, it was possible to develop a process to produce 1-10 μm particles of N-trimethylchitosan chloride (TMC) suitable for inhalation. Encapsulation of proteins in TMC using this technique could also be successfully achieved.
Original language | English (US) |
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Pages (from-to) | 216-224 |
Number of pages | 9 |
Journal | Journal of Supercritical Fluids |
Volume | 36 |
Issue number | 3 |
DOIs | |
State | Published - Jan 2006 |
Externally published | Yes |
Keywords
- N-trimethylchitosan chloride
- PCA
- Polymer micronisation
ASJC Scopus subject areas
- Condensed Matter Physics
- General Chemical Engineering
- Physical and Theoretical Chemistry