Opening new operating windows for polymer and protein micronisation using the PCA process

Y. Pérez De Diego; H. C. Pellikaan; F. E. Wubbolts; G. Borchard; G. J. Witkamp; P. J. Jansens

doi:10.1016/j.supflu.2005.06.008

Opening new operating windows for polymer and protein micronisation using the PCA process

Y. Pérez De Diego^*, H. C. Pellikaan, F. E. Wubbolts, G. Borchard, G. J. Witkamp, P. J. Jansens

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

To avoid the existing limitations of the PCA process for the precipitation of proteins and polar polymers a new approach based on the use of water to modify the phase behaviour of the system DMSO-CO₂ was developed. The addition of water to the DMSO displaces the mixture critical pressure of the solution-CO₂ system to higher pressures and produces a new operating region in which the PCA process can be carried out. Following this approach, it was possible to develop a process to produce 1-10 μm particles of N-trimethylchitosan chloride (TMC) suitable for inhalation. Encapsulation of proteins in TMC using this technique could also be successfully achieved.

Original language	English (US)
Pages (from-to)	216-224
Number of pages	9
Journal	Journal of Supercritical Fluids
Volume	36
Issue number	3
DOIs	https://doi.org/10.1016/j.supflu.2005.06.008
State	Published - Jan 2006
Externally published	Yes

Keywords

N-trimethylchitosan chloride
PCA
Polymer micronisation

ASJC Scopus subject areas

Condensed Matter Physics
General Chemical Engineering
Physical and Theoretical Chemistry

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10.1016/j.supflu.2005.06.008

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title = "Opening new operating windows for polymer and protein micronisation using the PCA process",

abstract = "To avoid the existing limitations of the PCA process for the precipitation of proteins and polar polymers a new approach based on the use of water to modify the phase behaviour of the system DMSO-CO2 was developed. The addition of water to the DMSO displaces the mixture critical pressure of the solution-CO2 system to higher pressures and produces a new operating region in which the PCA process can be carried out. Following this approach, it was possible to develop a process to produce 1-10 μm particles of N-trimethylchitosan chloride (TMC) suitable for inhalation. Encapsulation of proteins in TMC using this technique could also be successfully achieved.",

keywords = "N-trimethylchitosan chloride, PCA, Polymer micronisation",

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year = "2006",

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AU - Pérez De Diego, Y.

AU - Pellikaan, H. C.

AU - Wubbolts, F. E.

AU - Borchard, G.

AU - Witkamp, G. J.

AU - Jansens, P. J.

PY - 2006/1

Y1 - 2006/1

N2 - To avoid the existing limitations of the PCA process for the precipitation of proteins and polar polymers a new approach based on the use of water to modify the phase behaviour of the system DMSO-CO2 was developed. The addition of water to the DMSO displaces the mixture critical pressure of the solution-CO2 system to higher pressures and produces a new operating region in which the PCA process can be carried out. Following this approach, it was possible to develop a process to produce 1-10 μm particles of N-trimethylchitosan chloride (TMC) suitable for inhalation. Encapsulation of proteins in TMC using this technique could also be successfully achieved.

AB - To avoid the existing limitations of the PCA process for the precipitation of proteins and polar polymers a new approach based on the use of water to modify the phase behaviour of the system DMSO-CO2 was developed. The addition of water to the DMSO displaces the mixture critical pressure of the solution-CO2 system to higher pressures and produces a new operating region in which the PCA process can be carried out. Following this approach, it was possible to develop a process to produce 1-10 μm particles of N-trimethylchitosan chloride (TMC) suitable for inhalation. Encapsulation of proteins in TMC using this technique could also be successfully achieved.

KW - N-trimethylchitosan chloride

KW - PCA

KW - Polymer micronisation

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JO - Journal of Supercritical Fluids

JF - Journal of Supercritical Fluids

IS - 3

ER -

Opening new operating windows for polymer and protein micronisation using the PCA process

Abstract

Keywords

ASJC Scopus subject areas

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