Operation mechanism of n-type organic electronic metabolite sensors

Victor Druet, Prem Nayak, David Ohayon, Anil Koklu, Sahika Inal, Xingxing Chen, Maximilian Moser, Iain McCulloch

Research output: Chapter in Book/Report/Conference proceedingConference contribution


When combined with oxidase enzymes, the NDI-T2 based electron transporting (n-type) polymer led to high performance metabolite sensors, yet their working mechanism has been poorly understood.[1], [2] By monitoring oxygen, hydrogen peroxide, and pH changes in the electrolyte surrounding the n-type channel and gate as well as the potential of each electrical contact in the transistor, we shed light on the catalytic events occurring at the polymer-enzyme interface. We show that in its doped sate, the n-type film performs oxygen reduction reaction and that the n-OECT characteristics are sensitive to oxygen. We find a correlation between the amount of dissolved oxygen and the n-OECT sensor current generated during the metabolite oxidation and that using the n-type polymer at the gate electrode is critical for sensor operation. Our results show the importance of in operando analysis for understanding polymer-catalytic enzyme activity, as well as the importance of ambient oxygen in the operation of n-type devices.
Original languageEnglish (US)
Title of host publicationProceedings of the nanoGe Spring Meeting 2022
PublisherFundació Scito
StatePublished - Feb 7 2022


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