Organocatalytic enantioselective reduction of pyridines

Magnus Rueping; Andrey P. Antonchick

doi:10.1002/anie.200701158

Organocatalytic enantioselective reduction of pyridines

Magnus Rueping^*, Andrey P. Antonchick

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

255 Scopus citations

Abstract

Metal-free at last! The first enantioselective organocatalytic reduction of pyridine derivatives leads to hexahydrochinolinones and tetrahydropyridines in good yields and with excellent enantioselctivities (up to 92% ee; see scheme). These compounds are starting materials for the synthesis of various natural products.

Original language	English (US)
Pages (from-to)	4562-4565
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	46
Issue number	24
DOIs	https://doi.org/10.1002/anie.200701158
State	Published - 2007
Externally published	Yes

Keywords

Bronsted acids
Ion-pair catalysis
Piperidines
Reduction
Transfer hydrogenation

ASJC Scopus subject areas

Catalysis
General Chemistry

Access to Document

10.1002/anie.200701158

Cite this

@article{fabc007b864b460ba505f56452288629,

title = "Organocatalytic enantioselective reduction of pyridines",

abstract = "Metal-free at last! The first enantioselective organocatalytic reduction of pyridine derivatives leads to hexahydrochinolinones and tetrahydropyridines in good yields and with excellent enantioselctivities (up to 92% ee; see scheme). These compounds are starting materials for the synthesis of various natural products.",

keywords = "Bronsted acids, Ion-pair catalysis, Piperidines, Reduction, Transfer hydrogenation",

author = "Magnus Rueping and Antonchick, {Andrey P.}",

year = "2007",

doi = "10.1002/anie.200701158",

language = "English (US)",

volume = "46",

pages = "4562--4565",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "Wiley",

number = "24",

}

TY - JOUR

T1 - Organocatalytic enantioselective reduction of pyridines

AU - Rueping, Magnus

AU - Antonchick, Andrey P.

PY - 2007

Y1 - 2007

N2 - Metal-free at last! The first enantioselective organocatalytic reduction of pyridine derivatives leads to hexahydrochinolinones and tetrahydropyridines in good yields and with excellent enantioselctivities (up to 92% ee; see scheme). These compounds are starting materials for the synthesis of various natural products.

AB - Metal-free at last! The first enantioselective organocatalytic reduction of pyridine derivatives leads to hexahydrochinolinones and tetrahydropyridines in good yields and with excellent enantioselctivities (up to 92% ee; see scheme). These compounds are starting materials for the synthesis of various natural products.

KW - Bronsted acids

KW - Ion-pair catalysis

KW - Piperidines

KW - Reduction

KW - Transfer hydrogenation

UR - http://www.scopus.com/inward/record.url?scp=34250765230&partnerID=8YFLogxK

U2 - 10.1002/anie.200701158

DO - 10.1002/anie.200701158

M3 - Article

C2 - 17492817

AN - SCOPUS:34250765230

SN - 1433-7851

VL - 46

SP - 4562

EP - 4565

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 24

ER -

Organocatalytic enantioselective reduction of pyridines

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this