Overview of errors in the reference sequence and annotation of Mycobacterium tuberculosis H37Rv, and variation amongst its isolates

Claudio U. Köser; Stefan Niemann; David K. Summers; John A.C. Archer

doi:10.1016/j.meegid.2011.06.011

Overview of errors in the reference sequence and annotation of Mycobacterium tuberculosis H37Rv, and variation amongst its isolates

Claudio U. Köser, Stefan Niemann, David K. Summers, John A.C. Archer

Computer, Electrical and Mathematical Sciences and Engineering

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Since its publication in 1998, the genome sequence of the Mycobacterium tuberculosis H37Rv laboratory strain has acted as the cornerstone for the study of tuberculosis. In this review we address some of the practical aspects that have come to light relating to the use of H37Rv throughout the past decade which are of relevance for the ongoing genomic and laboratory studies of this pathogen. These include errors in the genome reference sequence and its annotation, as well as the recently detected variation amongst isolates of H37Rv from different laboratories. © 2011 Elsevier B.V..

Original language	English (US)
Pages (from-to)	807-810
Number of pages	4
Journal	Infection, Genetics and Evolution
Volume	12
Issue number	4
DOIs	https://doi.org/10.1016/j.meegid.2011.06.011
State	Published - Jun 2012

ASJC Scopus subject areas

Infectious Diseases
Ecology, Evolution, Behavior and Systematics
Genetics
Molecular Biology
Microbiology
Microbiology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.meegid.2011.06.011

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abstract = "Since its publication in 1998, the genome sequence of the Mycobacterium tuberculosis H37Rv laboratory strain has acted as the cornerstone for the study of tuberculosis. In this review we address some of the practical aspects that have come to light relating to the use of H37Rv throughout the past decade which are of relevance for the ongoing genomic and laboratory studies of this pathogen. These include errors in the genome reference sequence and its annotation, as well as the recently detected variation amongst isolates of H37Rv from different laboratories. {\textcopyright} 2011 Elsevier B.V..",

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AU - Summers, David K.

AU - Archer, John A.C.

N1 - KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: Claudio U. Koser is a Gates Cambridge Scholar and received additional funding from the Cambridge Philosophical Society, the Cambridge European Trust and Clare Hall, Cambridge. We thank D. Collins, J. Parkhill, F. Spies, and S. Okamo for sharing some of their data. We are also grateful to S. Gagneux for proofreading this paper.

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AB - Since its publication in 1998, the genome sequence of the Mycobacterium tuberculosis H37Rv laboratory strain has acted as the cornerstone for the study of tuberculosis. In this review we address some of the practical aspects that have come to light relating to the use of H37Rv throughout the past decade which are of relevance for the ongoing genomic and laboratory studies of this pathogen. These include errors in the genome reference sequence and its annotation, as well as the recently detected variation amongst isolates of H37Rv from different laboratories. © 2011 Elsevier B.V..

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Overview of errors in the reference sequence and annotation of Mycobacterium tuberculosis H37Rv, and variation amongst its isolates

Abstract

ASJC Scopus subject areas

UN SDGs

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