Abstract
A decarboxylative cyanation of amino acids under paired electrochemical reaction conditions has been developed. 4-CN-pyridine was found to be a new and effective cyanation reagent under catalyst-free conditions. Mechanistic studies support a nucleophilic reaction pathway, and the cyanation protocol can be applied to diverse substrates including N,N-dialkyl aniline and indole derivatives.
Original language | English (US) |
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Pages (from-to) | 6357-6363 |
Number of pages | 7 |
Journal | Organic Letters |
Volume | 24 |
Issue number | 35 |
DOIs | |
State | Published - Sep 9 2022 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry