Pentavalent antimony-mannan conjugate therapy of experimental visceral leishmaniasis

William L. Roberts; June Hariprashad; Petrie M. Rainey; Henry W. Murray

doi:10.4269/ajtmh.1996.55.444

Pentavalent antimony-mannan conjugate therapy of experimental visceral leishmaniasis

William L. Roberts, June Hariprashad, Petrie M. Rainey, Henry W. Murray

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Pentavalent antimony-mannan (Sb[V]-mannan) was 10-fold more potent than sodium stibogluconate in a murine model of visceral leishmaniasis. Liver antimony concentrations were six fold higher after Sb[V]-mannan therapy compared with a dose of sodium stibogluconate that was equipotent in reducing liver parasite burdens. Murine toxicity of Sb[V]-mannan was variable, with a 50% lethal dose (LD50) for one preparation that was well above the concentration that killed 90% of the parasites, and for another preparation was only modestly higher than the concentration that killed 90% of the parasites.

Original language	English (US)
Pages (from-to)	444-446
Number of pages	3
Journal	American Journal of Tropical Medicine and Hygiene
Volume	55
Issue number	4
DOIs	https://doi.org/10.4269/ajtmh.1996.55.444
State	Published - Jan 1 1996
Externally published	Yes

ASJC Scopus subject areas

Infectious Diseases
Virology
Parasitology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4269/ajtmh.1996.55.444

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title = "Pentavalent antimony-mannan conjugate therapy of experimental visceral leishmaniasis",

abstract = "Pentavalent antimony-mannan (Sb[V]-mannan) was 10-fold more potent than sodium stibogluconate in a murine model of visceral leishmaniasis. Liver antimony concentrations were six fold higher after Sb[V]-mannan therapy compared with a dose of sodium stibogluconate that was equipotent in reducing liver parasite burdens. Murine toxicity of Sb[V]-mannan was variable, with a 50% lethal dose (LD50) for one preparation that was well above the concentration that killed 90% of the parasites, and for another preparation was only modestly higher than the concentration that killed 90% of the parasites.",

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AU - Hariprashad, June

AU - Rainey, Petrie M.

AU - Murray, Henry W.

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AB - Pentavalent antimony-mannan (Sb[V]-mannan) was 10-fold more potent than sodium stibogluconate in a murine model of visceral leishmaniasis. Liver antimony concentrations were six fold higher after Sb[V]-mannan therapy compared with a dose of sodium stibogluconate that was equipotent in reducing liver parasite burdens. Murine toxicity of Sb[V]-mannan was variable, with a 50% lethal dose (LD50) for one preparation that was well above the concentration that killed 90% of the parasites, and for another preparation was only modestly higher than the concentration that killed 90% of the parasites.

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DO - 10.4269/ajtmh.1996.55.444

M3 - Article

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JO - American Journal of Tropical Medicine and Hygiene

JF - American Journal of Tropical Medicine and Hygiene

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ER -

Pentavalent antimony-mannan conjugate therapy of experimental visceral leishmaniasis

Abstract

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