Performance characteristics of six third-generation assays for thyroid-stimulating hormone

Mindy L. Rawlins, William L. Roberts

Research output: Contribution to journalArticlepeer-review

90 Scopus citations

Abstract

Background: Thyroid-stimulating hormone (TSH) is used to detect primary hypo- and hyperthyroidism. Current guidelines for TSH assays recommend a functional sensitivity of ≤0.02 mIU/L. The protocol for determining the functional sensitivity of TSH assays specifies analyses of serum samples with two reagent lots over a 6- to 8-week period. Methods: We determined the functional sensitivities of the Access 2, ADVIA Centaur, ARCHITECT i2000, E170, IMMULITE 2000, and Vitros ECi automated methods, using seven serum pools and two reagent lots for each method. Results: The observed functional sensitivities were as follows: Access 2,
Original languageEnglish (US)
Pages (from-to)2338-2344
Number of pages7
JournalClinical Chemistry
Volume50
Issue number12
DOIs
StatePublished - Dec 1 2004
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

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