Abstract
Background: Thyroid-stimulating hormone (TSH) is used to detect primary hypo- and hyperthyroidism. Current guidelines for TSH assays recommend a functional sensitivity of ≤0.02 mIU/L. The protocol for determining the functional sensitivity of TSH assays specifies analyses of serum samples with two reagent lots over a 6- to 8-week period. Methods: We determined the functional sensitivities of the Access 2, ADVIA Centaur, ARCHITECT i2000, E170, IMMULITE 2000, and Vitros ECi automated methods, using seven serum pools and two reagent lots for each method. Results: The observed functional sensitivities were as follows: Access 2,
Original language | English (US) |
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Pages (from-to) | 2338-2344 |
Number of pages | 7 |
Journal | Clinical Chemistry |
Volume | 50 |
Issue number | 12 |
DOIs | |
State | Published - Dec 1 2004 |
Externally published | Yes |
ASJC Scopus subject areas
- Clinical Biochemistry
- Biochemistry, medical