Permeability study of ciprofloxacin from ultra-thin nanofibrous film through various mucosal membranes

Vedant Modgill; Tarun Garg; Amit Kumar Goyal; Goutam Rath

doi:10.3109/21691401.2014.924007

Permeability study of ciprofloxacin from ultra-thin nanofibrous film through various mucosal membranes

Vedant Modgill, Tarun Garg, Amit Kumar Goyal, Goutam Rath

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Permeability plays an important role to achieve the desired therapeutic outcomes. Present study was designed to investigate the permeability of ciprofloxacin from ultrathin polyvinyl alcohol nanofiber through different biological membranes. Results of the permeability studies indicated that nanofibers exhibit higher drug permeability than plane drug. Intestinal tissue shows maximum permeability followed by eye, trachea, sublingual, rectal, and skin. Permeability studies also inferred a steady-state release of drug of the nanofiber, whereas a high degree of fluctuations was observed in plane drug. Nanofiber being 2D nanoscale material provides numerous advantages to be used as an encapsulated carrier system to improve the therapeutic effectiveness.

Original language	English (US)
Pages (from-to)	122-127
Number of pages	6
Journal	Artificial Cells, Nanomedicine and Biotechnology
Volume	44
Issue number	1
DOIs	https://doi.org/10.3109/21691401.2014.924007
State	Published - Jan 1 2016
Externally published	Yes

ASJC Scopus subject areas

Biotechnology
Biomedical Engineering
Pharmaceutical Science
Medicine (miscellaneous)

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10.3109/21691401.2014.924007

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Permeability study of ciprofloxacin from ultra-thin nanofibrous film through various mucosal membranes

Abstract

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