pH clock-operated mechanized nanoparticles

Sarah Angelos, Nivine Khachab, Ying Wei Yang, Ali Trabolsi, Hussam A. Khatib, J. Fraser Stoddart, Jeffrey I. Zink

Research output: Contribution to journalArticlepeer-review

311 Scopus citations


Mechanized nanoparticles (MNPs) consisting of supramolecular machines attached to the surface of mesoporous silica nanoparticles are designed to release encapsulated guest molecules controllably under pH activation. The molecular machines are comprised of cucurbit[6]uril (CB[6]) rings that encircle tethered trisammonium stalks and can be tuned to respond under specific pH conditions through chemical modification of the stalks. Luminescence spectroscopy demonstrates that the MNPs are able to contain guest molecules within nanopores at neutral pH levels and then release them once the pH is lowered or raised.

Original languageEnglish (US)
Pages (from-to)12912-12914
Number of pages3
JournalJournal of the American Chemical Society
Issue number36
StatePublished - Sep 16 2009

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry


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