pH-responsive micelles and vesicles nanocapsules based on polypeptide diblock copolymers

F. Chécot; J. Rodríguez-Hernández; Y. Gnanou; S. Lecommandoux

doi:10.1016/j.bioeng.2006.05.015

pH-responsive micelles and vesicles nanocapsules based on polypeptide diblock copolymers

F. Chécot, J. Rodríguez-Hernández, Y. Gnanou, S. Lecommandoux^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

100 Scopus citations

Abstract

The self-assembly of well-defined polypeptide-based diblock copolymers into micelles and vesicles is presented. The stimuli-responsive behavior of polypeptides to pH and ionic strength is used to produce stimuli-responsive nanoparticles with controlled size and shape. Results focusing on micelles and vesicles obtained from polypeptide-based diblock copolymers that are particularly promising for biomedical applications are detailed by means of static and dynamic light scattering analysis, UV circular dichroism, NMR and small angle neutron scattering experiments. Also systems able to form vesicles with a narrow size distribution at basic and acid pH going through a single molecule intermediate state are presented. These nanoparticles are particularly interesting for encapsulation and delivery purpose at a controlled pH.

Original language	English (US)
Pages (from-to)	81-85
Number of pages	5
Journal	Biomolecular Engineering
Volume	24
Issue number	1 SPEC. ISS.
DOIs	https://doi.org/10.1016/j.bioeng.2006.05.015
State	Published - Feb 2007
Externally published	Yes

Keywords

Block copolymers
Polypeptide
Self-assembly
Vesicle

ASJC Scopus subject areas

Bioengineering
Molecular Biology
Biotechnology

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10.1016/j.bioeng.2006.05.015

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title = "pH-responsive micelles and vesicles nanocapsules based on polypeptide diblock copolymers",

abstract = "The self-assembly of well-defined polypeptide-based diblock copolymers into micelles and vesicles is presented. The stimuli-responsive behavior of polypeptides to pH and ionic strength is used to produce stimuli-responsive nanoparticles with controlled size and shape. Results focusing on micelles and vesicles obtained from polypeptide-based diblock copolymers that are particularly promising for biomedical applications are detailed by means of static and dynamic light scattering analysis, UV circular dichroism, NMR and small angle neutron scattering experiments. Also systems able to form vesicles with a narrow size distribution at basic and acid pH going through a single molecule intermediate state are presented. These nanoparticles are particularly interesting for encapsulation and delivery purpose at a controlled pH.",

keywords = "Block copolymers, Polypeptide, Self-assembly, Vesicle",

author = "F. Ch{\'e}cot and J. Rodr{\'i}guez-Hern{\'a}ndez and Y. Gnanou and S. Lecommandoux",

year = "2007",

month = feb,

doi = "10.1016/j.bioeng.2006.05.015",

language = "English (US)",

volume = "24",

pages = "81--85",

journal = "Biomolecular Engineering",

issn = "1389-0344",

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T1 - pH-responsive micelles and vesicles nanocapsules based on polypeptide diblock copolymers

AU - Chécot, F.

AU - Rodríguez-Hernández, J.

AU - Gnanou, Y.

AU - Lecommandoux, S.

PY - 2007/2

Y1 - 2007/2

N2 - The self-assembly of well-defined polypeptide-based diblock copolymers into micelles and vesicles is presented. The stimuli-responsive behavior of polypeptides to pH and ionic strength is used to produce stimuli-responsive nanoparticles with controlled size and shape. Results focusing on micelles and vesicles obtained from polypeptide-based diblock copolymers that are particularly promising for biomedical applications are detailed by means of static and dynamic light scattering analysis, UV circular dichroism, NMR and small angle neutron scattering experiments. Also systems able to form vesicles with a narrow size distribution at basic and acid pH going through a single molecule intermediate state are presented. These nanoparticles are particularly interesting for encapsulation and delivery purpose at a controlled pH.

AB - The self-assembly of well-defined polypeptide-based diblock copolymers into micelles and vesicles is presented. The stimuli-responsive behavior of polypeptides to pH and ionic strength is used to produce stimuli-responsive nanoparticles with controlled size and shape. Results focusing on micelles and vesicles obtained from polypeptide-based diblock copolymers that are particularly promising for biomedical applications are detailed by means of static and dynamic light scattering analysis, UV circular dichroism, NMR and small angle neutron scattering experiments. Also systems able to form vesicles with a narrow size distribution at basic and acid pH going through a single molecule intermediate state are presented. These nanoparticles are particularly interesting for encapsulation and delivery purpose at a controlled pH.

KW - Block copolymers

KW - Polypeptide

KW - Self-assembly

KW - Vesicle

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U2 - 10.1016/j.bioeng.2006.05.015

DO - 10.1016/j.bioeng.2006.05.015

M3 - Article

C2 - 16870504

AN - SCOPUS:33846809234

SN - 1389-0344

VL - 24

SP - 81

EP - 85

JO - Biomolecular Engineering

JF - Biomolecular Engineering

IS - 1 SPEC. ISS.

ER -

pH-responsive micelles and vesicles nanocapsules based on polypeptide diblock copolymers

Abstract

Keywords

ASJC Scopus subject areas

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