Photodetection of early cancer by laser induced fluorescence of a tumor-selective dye. Apparatus design and realization

G. Wagnieres; Ch Depeursinge; Ph Monnier; M. Savary; P. Cornaz; A. Chatelain; H. van den Bergh

doi:10.1117/12.17649

Photodetection of early cancer by laser induced fluorescence of a tumor-selective dye. Apparatus design and realization

G. Wagnieres^*, Ch Depeursinge, Ph Monnier, M. Savary, P. Cornaz, A. Chatelain, H. van den Bergh

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

28 Scopus citations

Abstract

An apparatus is designed and realized to detect 'early' cancer at the surface of the hollow organs in the human body by endoscopic means. The tumor is localized by the laser induced fluorescence of a dye (HPD) which concentrates selectively in the neoplastic tissue after intravenous injection. Fluorescence contrast between the tumor and its normal surroundings is enhanced by subtracting the background autofluorescence which occurs in both types of tissue. This is done by means of 2-color digital images manipulation in real-time. Preliminary clinical tests of the apparatus demonstrated the detection of carcinoma in situ in the esophagus.

Original language	English (US)
Title of host publication	Proceedings of SPIE - The International Society for Optical Engineering
Publisher	Publ by Int Soc for Optical Engineering
Pages	43-52
Number of pages	10
ISBN (Print)	0819402443, 9780819402448
DOIs	https://doi.org/10.1117/12.17649
State	Published - 1990
Externally published	Yes
Event	Proceedings of Photodynamic Therapy: Mechanisms II - Los Angeles, CA, USA Duration: Jan 16 1990 → Jan 17 1990

Publication series

Name	Proceedings of SPIE - The International Society for Optical Engineering
Volume	1203
ISSN (Print)	0277-786X

Other

Other	Proceedings of Photodynamic Therapy: Mechanisms II
City	Los Angeles, CA, USA
Period	01/16/90 → 01/17/90

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Computer Science Applications
Applied Mathematics
Electrical and Electronic Engineering

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1117/12.17649

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Wagnieres, G., Depeursinge, C., Monnier, P., Savary, M., Cornaz, P., Chatelain, A., & van den Bergh, H. (1990). Photodetection of early cancer by laser induced fluorescence of a tumor-selective dye. Apparatus design and realization. In Proceedings of SPIE - The International Society for Optical Engineering (pp. 43-52). (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 1203). Publ by Int Soc for Optical Engineering. https://doi.org/10.1117/12.17649

Wagnieres, G. ; Depeursinge, Ch ; Monnier, Ph et al. / Photodetection of early cancer by laser induced fluorescence of a tumor-selective dye. Apparatus design and realization. Proceedings of SPIE - The International Society for Optical Engineering. Publ by Int Soc for Optical Engineering, 1990. pp. 43-52 (Proceedings of SPIE - The International Society for Optical Engineering).

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title = "Photodetection of early cancer by laser induced fluorescence of a tumor-selective dye. Apparatus design and realization",

abstract = "An apparatus is designed and realized to detect 'early' cancer at the surface of the hollow organs in the human body by endoscopic means. The tumor is localized by the laser induced fluorescence of a dye (HPD) which concentrates selectively in the neoplastic tissue after intravenous injection. Fluorescence contrast between the tumor and its normal surroundings is enhanced by subtracting the background autofluorescence which occurs in both types of tissue. This is done by means of 2-color digital images manipulation in real-time. Preliminary clinical tests of the apparatus demonstrated the detection of carcinoma in situ in the esophagus.",

author = "G. Wagnieres and Ch Depeursinge and Ph Monnier and M. Savary and P. Cornaz and A. Chatelain and {van den Bergh}, H.",

year = "1990",

doi = "10.1117/12.17649",

language = "English (US)",

isbn = "0819402443",

series = "Proceedings of SPIE - The International Society for Optical Engineering",

publisher = "Publ by Int Soc for Optical Engineering",

pages = "43--52",

booktitle = "Proceedings of SPIE - The International Society for Optical Engineering",

note = "Proceedings of Photodynamic Therapy: Mechanisms II ; Conference date: 16-01-1990 Through 17-01-1990",

}

Wagnieres, G, Depeursinge, C, Monnier, P, Savary, M, Cornaz, P, Chatelain, A & van den Bergh, H 1990, Photodetection of early cancer by laser induced fluorescence of a tumor-selective dye. Apparatus design and realization. in Proceedings of SPIE - The International Society for Optical Engineering. Proceedings of SPIE - The International Society for Optical Engineering, vol. 1203, Publ by Int Soc for Optical Engineering, pp. 43-52, Proceedings of Photodynamic Therapy: Mechanisms II, Los Angeles, CA, USA, 01/16/90. https://doi.org/10.1117/12.17649

Photodetection of early cancer by laser induced fluorescence of a tumor-selective dye. Apparatus design and realization. / Wagnieres, G.; Depeursinge, Ch; Monnier, Ph et al.
Proceedings of SPIE - The International Society for Optical Engineering. Publ by Int Soc for Optical Engineering, 1990. p. 43-52 (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 1203).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Photodetection of early cancer by laser induced fluorescence of a tumor-selective dye. Apparatus design and realization

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AU - Depeursinge, Ch

AU - Monnier, Ph

AU - Savary, M.

AU - Cornaz, P.

AU - Chatelain, A.

AU - van den Bergh, H.

PY - 1990

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AB - An apparatus is designed and realized to detect 'early' cancer at the surface of the hollow organs in the human body by endoscopic means. The tumor is localized by the laser induced fluorescence of a dye (HPD) which concentrates selectively in the neoplastic tissue after intravenous injection. Fluorescence contrast between the tumor and its normal surroundings is enhanced by subtracting the background autofluorescence which occurs in both types of tissue. This is done by means of 2-color digital images manipulation in real-time. Preliminary clinical tests of the apparatus demonstrated the detection of carcinoma in situ in the esophagus.

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M3 - Conference contribution

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SN - 9780819402448

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BT - Proceedings of SPIE - The International Society for Optical Engineering

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ER -

Wagnieres G, Depeursinge C, Monnier P, Savary M, Cornaz P, Chatelain A et al. Photodetection of early cancer by laser induced fluorescence of a tumor-selective dye. Apparatus design and realization. In Proceedings of SPIE - The International Society for Optical Engineering. Publ by Int Soc for Optical Engineering. 1990. p. 43-52. (Proceedings of SPIE - The International Society for Optical Engineering). doi: 10.1117/12.17649

Photodetection of early cancer by laser induced fluorescence of a tumor-selective dye. Apparatus design and realization

Abstract

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