Photosensitizer decorated iron oxide nanoparticles: Bimodal agent for combined hyperthermia and photodynamic therapy

Zhimou Yang; Keming Xu; Bei Zhang; Bing Xu; Xixiang Zhang; Chi K. Chang

doi:10.1117/12.646341

Photosensitizer decorated iron oxide nanoparticles: Bimodal agent for combined hyperthermia and photodynamic therapy

Zhimou Yang, Keming Xu, Bei Zhang, Bing Xu, Xixiang Zhang, Chi K. Chang^*

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1 Scopus citations

Abstract

As the PDT effect may be enhanced by localized hyperthermia (HT), it would be logical to find a single agent that could bring about these two modalities at precisely the target site for synergism. Since highly localized HT can be induced by magnetic field excitation of superparamagnetic nanoparticles, we report here the design and synthesis of photosensitizer-decorated iron oxide nanoparticles and their tumoricidal effect. Thus, a porphyrin is covalently anchored on the iron oxide nanoparticle via dihydroxybenzene which binds tightly on the surface of the nanoparticle by M-O bond. The morphology of the resultant nanoparticle was studied to show that the crystallinality is not changed and the nanoparticle remains superparamagnetic at room temperature. The conjugate is also strongly fluorescent indicating that the iron oxide hardly affects the optical properties of the surface bound porphyrin moieties. The conjugate is readily taken by cancer cell (Hela cell line) and is able to trigger apoptosis after excitation by light.

Original language	English (US)
Title of host publication	Optical Methods for Tumor Treatment and Detection
Subtitle of host publication	Mechanisms and Techniques in Photodynamic Therapy XV
DOIs	https://doi.org/10.1117/12.646341
State	Published - 2006
Externally published	Yes
Event	Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XV - San Jose, CA, United States Duration: Jan 21 2006 → Jan 22 2006

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	6139
ISSN (Print)	1605-7422

Other

Other	Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XV
Country/Territory	United States
City	San Jose, CA
Period	01/21/06 → 01/22/06

Keywords

Feo
Hyperthermia
Magnetic nanoparticle
Porphyrin

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Atomic and Molecular Physics, and Optics
Radiology Nuclear Medicine and imaging
Biomaterials

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1117/12.646341

Cite this

Yang, Z., Xu, K., Zhang, B., Xu, B., Zhang, X., & Chang, C. K. (2006). Photosensitizer decorated iron oxide nanoparticles: Bimodal agent for combined hyperthermia and photodynamic therapy. In Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XV Article 613906 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6139). https://doi.org/10.1117/12.646341

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title = "Photosensitizer decorated iron oxide nanoparticles: Bimodal agent for combined hyperthermia and photodynamic therapy",

abstract = "As the PDT effect may be enhanced by localized hyperthermia (HT), it would be logical to find a single agent that could bring about these two modalities at precisely the target site for synergism. Since highly localized HT can be induced by magnetic field excitation of superparamagnetic nanoparticles, we report here the design and synthesis of photosensitizer-decorated iron oxide nanoparticles and their tumoricidal effect. Thus, a porphyrin is covalently anchored on the iron oxide nanoparticle via dihydroxybenzene which binds tightly on the surface of the nanoparticle by M-O bond. The morphology of the resultant nanoparticle was studied to show that the crystallinality is not changed and the nanoparticle remains superparamagnetic at room temperature. The conjugate is also strongly fluorescent indicating that the iron oxide hardly affects the optical properties of the surface bound porphyrin moieties. The conjugate is readily taken by cancer cell (Hela cell line) and is able to trigger apoptosis after excitation by light.",

keywords = "Feo, Hyperthermia, Magnetic nanoparticle, Porphyrin",

author = "Zhimou Yang and Keming Xu and Bei Zhang and Bing Xu and Xixiang Zhang and Chang, {Chi K.}",

year = "2006",

doi = "10.1117/12.646341",

language = "English (US)",

isbn = "0819461822",

series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

booktitle = "Optical Methods for Tumor Treatment and Detection",

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}

Yang, Z, Xu, K, Zhang, B, Xu, B, Zhang, X & Chang, CK 2006, Photosensitizer decorated iron oxide nanoparticles: Bimodal agent for combined hyperthermia and photodynamic therapy. in Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XV., 613906, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 6139, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XV, San Jose, CA, United States, 01/21/06. https://doi.org/10.1117/12.646341

Photosensitizer decorated iron oxide nanoparticles: Bimodal agent for combined hyperthermia and photodynamic therapy. / Yang, Zhimou; Xu, Keming; Zhang, Bei et al.
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XV. 2006. 613906 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6139).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Photosensitizer decorated iron oxide nanoparticles

T2 - Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XV

AU - Yang, Zhimou

AU - Xu, Keming

AU - Zhang, Bei

AU - Xu, Bing

AU - Zhang, Xixiang

AU - Chang, Chi K.

PY - 2006

Y1 - 2006

N2 - As the PDT effect may be enhanced by localized hyperthermia (HT), it would be logical to find a single agent that could bring about these two modalities at precisely the target site for synergism. Since highly localized HT can be induced by magnetic field excitation of superparamagnetic nanoparticles, we report here the design and synthesis of photosensitizer-decorated iron oxide nanoparticles and their tumoricidal effect. Thus, a porphyrin is covalently anchored on the iron oxide nanoparticle via dihydroxybenzene which binds tightly on the surface of the nanoparticle by M-O bond. The morphology of the resultant nanoparticle was studied to show that the crystallinality is not changed and the nanoparticle remains superparamagnetic at room temperature. The conjugate is also strongly fluorescent indicating that the iron oxide hardly affects the optical properties of the surface bound porphyrin moieties. The conjugate is readily taken by cancer cell (Hela cell line) and is able to trigger apoptosis after excitation by light.

AB - As the PDT effect may be enhanced by localized hyperthermia (HT), it would be logical to find a single agent that could bring about these two modalities at precisely the target site for synergism. Since highly localized HT can be induced by magnetic field excitation of superparamagnetic nanoparticles, we report here the design and synthesis of photosensitizer-decorated iron oxide nanoparticles and their tumoricidal effect. Thus, a porphyrin is covalently anchored on the iron oxide nanoparticle via dihydroxybenzene which binds tightly on the surface of the nanoparticle by M-O bond. The morphology of the resultant nanoparticle was studied to show that the crystallinality is not changed and the nanoparticle remains superparamagnetic at room temperature. The conjugate is also strongly fluorescent indicating that the iron oxide hardly affects the optical properties of the surface bound porphyrin moieties. The conjugate is readily taken by cancer cell (Hela cell line) and is able to trigger apoptosis after excitation by light.

KW - Feo

KW - Hyperthermia

KW - Magnetic nanoparticle

KW - Porphyrin

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M3 - Conference contribution

AN - SCOPUS:33745395683

SN - 0819461822

SN - 9780819461827

T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

BT - Optical Methods for Tumor Treatment and Detection

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ER -

Yang Z, Xu K, Zhang B, Xu B, Zhang X, Chang CK. Photosensitizer decorated iron oxide nanoparticles: Bimodal agent for combined hyperthermia and photodynamic therapy. In Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XV. 2006. 613906. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). doi: 10.1117/12.646341

Photosensitizer decorated iron oxide nanoparticles: Bimodal agent for combined hyperthermia and photodynamic therapy

Abstract

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Keywords

ASJC Scopus subject areas

UN SDGs

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