Pilot study of myocardial ischemia-induced metabolomic changes in emergency department patients undergoing stress testing

Alexander T. Limkakeng; Ricardo Henao; Deepak Voora; Thomas O'Connell; Michelle Griffin; Ephraim L. Tsalik; Svati Shah; Christopher W. Woods; Geoffrey S. Ginsburg

doi:10.1371/journal.pone.0211762

Pilot study of myocardial ischemia-induced metabolomic changes in emergency department patients undergoing stress testing

Alexander T. Limkakeng, Ricardo Henao, Deepak Voora, Thomas O'Connell, Michelle Griffin, Ephraim L. Tsalik, Svati Shah, Christopher W. Woods, Geoffrey S. Ginsburg

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Background The heart is a metabolically active organ, and plasma acylcarnitines are associated with long-term risk for myocardial infarction. We hypothesized that myocardial ischemia from cardiac stress testing will produce dynamic changes in acylcarnitine and amino acid levels compared to levels seen in matched control patients with normal stress tests. Methods We analyzed targeted metabolomic profiles in a pilot study of 20 case patients with inducible ischemia on stress testing from an existing prospectively collected repository of 357 consecutive patients presenting with symptoms of Acute Coronary Syndrome (ACS) in an Emergency Department (ED) observation unit between November 2012 and September 2014. We selected 20 controls matched on age, sex, and body-mass index (BMI). A peripheral blood sample was drawn

Original language	English (US)
Journal	PloS one
Volume	14
Issue number	2
DOIs	https://doi.org/10.1371/journal.pone.0211762
State	Published - Jul 1 2019
Externally published	Yes

ASJC Scopus subject areas

General Agricultural and Biological Sciences
General Biochemistry, Genetics and Molecular Biology
General Medicine

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title = "Pilot study of myocardial ischemia-induced metabolomic changes in emergency department patients undergoing stress testing",

abstract = "Background The heart is a metabolically active organ, and plasma acylcarnitines are associated with long-term risk for myocardial infarction. We hypothesized that myocardial ischemia from cardiac stress testing will produce dynamic changes in acylcarnitine and amino acid levels compared to levels seen in matched control patients with normal stress tests. Methods We analyzed targeted metabolomic profiles in a pilot study of 20 case patients with inducible ischemia on stress testing from an existing prospectively collected repository of 357 consecutive patients presenting with symptoms of Acute Coronary Syndrome (ACS) in an Emergency Department (ED) observation unit between November 2012 and September 2014. We selected 20 controls matched on age, sex, and body-mass index (BMI). A peripheral blood sample was drawn",

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AU - Limkakeng, Alexander T.

AU - Henao, Ricardo

AU - Voora, Deepak

AU - O'Connell, Thomas

AU - Griffin, Michelle

AU - Tsalik, Ephraim L.

AU - Shah, Svati

AU - Woods, Christopher W.

AU - Ginsburg, Geoffrey S.

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PY - 2019/7/1

Y1 - 2019/7/1

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AB - Background The heart is a metabolically active organ, and plasma acylcarnitines are associated with long-term risk for myocardial infarction. We hypothesized that myocardial ischemia from cardiac stress testing will produce dynamic changes in acylcarnitine and amino acid levels compared to levels seen in matched control patients with normal stress tests. Methods We analyzed targeted metabolomic profiles in a pilot study of 20 case patients with inducible ischemia on stress testing from an existing prospectively collected repository of 357 consecutive patients presenting with symptoms of Acute Coronary Syndrome (ACS) in an Emergency Department (ED) observation unit between November 2012 and September 2014. We selected 20 controls matched on age, sex, and body-mass index (BMI). A peripheral blood sample was drawn

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Pilot study of myocardial ischemia-induced metabolomic changes in emergency department patients undergoing stress testing

Abstract

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