TY - JOUR
T1 - Plant transducers of the endoplasmic reticulum unfolded protein response
AU - Iwata, Yuji
AU - Koizumi, Nozomu
N1 - KAUST Repository Item: Exported on 2020-10-01
PY - 2012/12
Y1 - 2012/12
N2 - The unfolded protein response (UPR) activates a set of genes to overcome accumulation of unfolded proteins in the endoplasmic reticulum (ER), a condition termed ER stress, and constitutes an essential part of ER protein quality control that ensures efficient maturation of secretory and membrane proteins in eukaryotes. Recent studies on Arabidopsis and rice identified the signaling pathway in which the ER membrane-localized ribonuclease IRE1 (inositol-requiring enzyme 1) catalyzes unconventional cytoplasmic splicing of mRNA, thereby producing the active transcription factor Arabidopsis bZIP60 (basic leucine zipper 60) and its ortholog in rice. Here we review recent findings identifying the molecular components of the plant UPR, including IRE1/bZIP60 and the membrane-bound transcription factors bZIP17 and bZIP28, and implicating its importance in several physiological phenomena such as pathogen response. © 2012 Elsevier Ltd.
AB - The unfolded protein response (UPR) activates a set of genes to overcome accumulation of unfolded proteins in the endoplasmic reticulum (ER), a condition termed ER stress, and constitutes an essential part of ER protein quality control that ensures efficient maturation of secretory and membrane proteins in eukaryotes. Recent studies on Arabidopsis and rice identified the signaling pathway in which the ER membrane-localized ribonuclease IRE1 (inositol-requiring enzyme 1) catalyzes unconventional cytoplasmic splicing of mRNA, thereby producing the active transcription factor Arabidopsis bZIP60 (basic leucine zipper 60) and its ortholog in rice. Here we review recent findings identifying the molecular components of the plant UPR, including IRE1/bZIP60 and the membrane-bound transcription factors bZIP17 and bZIP28, and implicating its importance in several physiological phenomena such as pathogen response. © 2012 Elsevier Ltd.
UR - http://hdl.handle.net/10754/566016
UR - https://linkinghub.elsevier.com/retrieve/pii/S1360138512001537
UR - http://www.scopus.com/inward/record.url?scp=84870293462&partnerID=8YFLogxK
U2 - 10.1016/j.tplants.2012.06.014
DO - 10.1016/j.tplants.2012.06.014
M3 - Article
C2 - 22796463
SN - 1360-1385
VL - 17
SP - 720
EP - 727
JO - Trends in Plant Science
JF - Trends in Plant Science
IS - 12
ER -