Plasmon based biosensor for distinguishing different peptides mutation states

Gobind Das; Manohar Chirumamilla; Andrea Toma; Anisha Gopalakrishnan; Remo Proietti Zaccaria; Alessandro Alabastri; Marco Leoncini; Enzo M. Di Fabrizio

doi:10.1038/srep01792

Plasmon based biosensor for distinguishing different peptides mutation states

Gobind Das, Manohar Chirumamilla, Andrea Toma, Anisha Gopalakrishnan, Remo Proietti Zaccaria, Alessandro Alabastri, Marco Leoncini, Enzo M. Di Fabrizio

Research output: Contribution to journal › Article › peer-review

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Abstract

Periodic and reproducible gold nanocuboids with various matrix dimensions and with different inter-particle gaps were fabricated by means of top-down technique. Rhodamine 6G was used as a probe molecule to optimize the design and the fabrication of the cuboid nanostructures. The electric field distribution for the nanocuboids with varying matrix dimensions/inter-particle gap was also investigated. These SERS devices were employed as biosensors through the investigation of both myoglobin and wild/mutated peptides. The results demonstrate the probing and the screening of wild/mutated BRCA1 peptides, thus opening a path for the fabrication of simple and cheap SERS device capable of early detection of several diseases.

Original language	English (US)
Journal	Scientific Reports
Volume	3
Issue number	1
DOIs	https://doi.org/10.1038/srep01792
State	Published - May 8 2013

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10.1038/srep01792

https://repository.kaust.edu.sa/bitstream/10754/325383/1/Article-Scientific-Plasmon_ba-2013.pdf

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title = "Plasmon based biosensor for distinguishing different peptides mutation states",

abstract = "Periodic and reproducible gold nanocuboids with various matrix dimensions and with different inter-particle gaps were fabricated by means of top-down technique. Rhodamine 6G was used as a probe molecule to optimize the design and the fabrication of the cuboid nanostructures. The electric field distribution for the nanocuboids with varying matrix dimensions/inter-particle gap was also investigated. These SERS devices were employed as biosensors through the investigation of both myoglobin and wild/mutated peptides. The results demonstrate the probing and the screening of wild/mutated BRCA1 peptides, thus opening a path for the fabrication of simple and cheap SERS device capable of early detection of several diseases.",

author = "Gobind Das and Manohar Chirumamilla and Andrea Toma and Anisha Gopalakrishnan and Zaccaria, {Remo Proietti} and Alessandro Alabastri and Marco Leoncini and {Di Fabrizio}, {Enzo M.}",

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T1 - Plasmon based biosensor for distinguishing different peptides mutation states

AU - Das, Gobind

AU - Chirumamilla, Manohar

AU - Toma, Andrea

AU - Gopalakrishnan, Anisha

AU - Zaccaria, Remo Proietti

AU - Alabastri, Alessandro

AU - Leoncini, Marco

AU - Di Fabrizio, Enzo M.

N1 - KAUST Repository Item: Exported on 2020-10-01

PY - 2013/5/8

Y1 - 2013/5/8

N2 - Periodic and reproducible gold nanocuboids with various matrix dimensions and with different inter-particle gaps were fabricated by means of top-down technique. Rhodamine 6G was used as a probe molecule to optimize the design and the fabrication of the cuboid nanostructures. The electric field distribution for the nanocuboids with varying matrix dimensions/inter-particle gap was also investigated. These SERS devices were employed as biosensors through the investigation of both myoglobin and wild/mutated peptides. The results demonstrate the probing and the screening of wild/mutated BRCA1 peptides, thus opening a path for the fabrication of simple and cheap SERS device capable of early detection of several diseases.

AB - Periodic and reproducible gold nanocuboids with various matrix dimensions and with different inter-particle gaps were fabricated by means of top-down technique. Rhodamine 6G was used as a probe molecule to optimize the design and the fabrication of the cuboid nanostructures. The electric field distribution for the nanocuboids with varying matrix dimensions/inter-particle gap was also investigated. These SERS devices were employed as biosensors through the investigation of both myoglobin and wild/mutated peptides. The results demonstrate the probing and the screening of wild/mutated BRCA1 peptides, thus opening a path for the fabrication of simple and cheap SERS device capable of early detection of several diseases.

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Plasmon based biosensor for distinguishing different peptides mutation states

Abstract

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