Poly(amino ester)s as an emerging synthetic biodegradable polymer platform: Recent developments and future trends

Xin Wang, Zhengbiao Zhang, Nikos Hadjichristidis

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Poly(amino ester)s (PAEs) refer to a class of synthetic polymers characterized by repeating units in the backbone having tertiary amines and ester bonds, and bringing together the inherent biodegradability of polyesters and the rich tunable functionalities provided by tertiary amines. The presence of tertiary amines allows the introduction of various pendant groups, leading to diverse PAE material and properties, such as biodegradability, biocompatibility, water-solubility, stimulus-responsiveness (pH or temperature), etc. To date, PAEs are evolving into a new class of biodegradable polymer materials independent of aliphatic polyesters and have been widely used in various biomedical fields, such as gene delivery, drug delivery, bioimaging agents, etc. In addition, a new family of PAEs, namely N-acylated PAEs, with the same pendant carbonyl groups as poly(2-oxazoline)s, is expected to develop into new biopolymer platforms similar to polypeptoids and polyoxazolines. This review comprehensively summarizes the synthesis methods of PAEs, including polycondensation (PCD), Michael addition polymerization (MAP), spontaneous zwitterionic copolymerization (SZWIP), and ring-opening polymerization (ROP).
Original languageEnglish (US)
Pages (from-to)101634
JournalProgress in Polymer Science
Volume136
DOIs
StatePublished - Nov 24 2022

ASJC Scopus subject areas

  • Materials Chemistry
  • Organic Chemistry
  • Polymers and Plastics
  • Ceramics and Composites
  • Surfaces and Interfaces

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