Polycomb, epigenomes, and control of cell identity

Valerio Orlando*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

295 Scopus citations


In development, cell identity is maintained by epigenetic functions that prevent changes in cell type-specific transcription programs. Recent insights into gene silencing mechanisms by Polycomb group (PcG) and trithorax group (trxG) proteins reveal that the memory system involves a concerted process of chromatin modification, blocking of RNA polymerase II, and synthesis of noncoding RNA. Remarkably, cell memory is regulated by a balance between repressors and activators that maintains both transcription status and at the same time the possibility of switching to a different state.

Original languageEnglish (US)
Pages (from-to)599-606
Number of pages8
Issue number5
StatePublished - Mar 7 2003
Externally publishedYes

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


Dive into the research topics of 'Polycomb, epigenomes, and control of cell identity'. Together they form a unique fingerprint.

Cite this