Polymer- versus Silica-Based Separation Media: Elimination of Nonspecific Interactions in the Chiral Recognition Process through Functional Polymer Design

Yuelong Liu; Frantisek Svec; Jean M.J. Fréchet; Kathy N. Juneau

doi:10.1021/ac960708p

Polymer- versus Silica-Based Separation Media: Elimination of Nonspecific Interactions in the Chiral Recognition Process through Functional Polymer Design

Yuelong Liu, Frantisek Svec, Jean M.J. Fréchet^*, Kathy N. Juneau

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

A novel chiral stationary phase that contains a new chiral selector based on L-valine-3,5-dimethylanilide attached to monodisperse poly(glycidyl methacrylate-co-ethylene dimethacrylate) beads has been prepared. The polymeric separation medium provides greatly enhanced enantioselectivities and reduced retention times when compared to me analogous silica-based chiral stationary phase in the separation of the enantiomers of 3,5-dinitrobenzamido derivatives of α-amino acids under normal-phase HPLC conditions. Separation factors (α) of up to 7 were achieved with the polymeric separation medium, which is also useful for the separation of large samples under overload conditions.

Original language	English (US)
Pages (from-to)	61-65
Number of pages	5
Journal	ANALYTICAL CHEMISTRY
Volume	69
Issue number	1
DOIs	https://doi.org/10.1021/ac960708p
State	Published - 1997
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry

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abstract = "A novel chiral stationary phase that contains a new chiral selector based on L-valine-3,5-dimethylanilide attached to monodisperse poly(glycidyl methacrylate-co-ethylene dimethacrylate) beads has been prepared. The polymeric separation medium provides greatly enhanced enantioselectivities and reduced retention times when compared to me analogous silica-based chiral stationary phase in the separation of the enantiomers of 3,5-dinitrobenzamido derivatives of α-amino acids under normal-phase HPLC conditions. Separation factors (α) of up to 7 were achieved with the polymeric separation medium, which is also useful for the separation of large samples under overload conditions.",

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AU - Fréchet, Jean M.J.

AU - Juneau, Kathy N.

PY - 1997

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AB - A novel chiral stationary phase that contains a new chiral selector based on L-valine-3,5-dimethylanilide attached to monodisperse poly(glycidyl methacrylate-co-ethylene dimethacrylate) beads has been prepared. The polymeric separation medium provides greatly enhanced enantioselectivities and reduced retention times when compared to me analogous silica-based chiral stationary phase in the separation of the enantiomers of 3,5-dinitrobenzamido derivatives of α-amino acids under normal-phase HPLC conditions. Separation factors (α) of up to 7 were achieved with the polymeric separation medium, which is also useful for the separation of large samples under overload conditions.

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Polymer- versus Silica-Based Separation Media: Elimination of Nonspecific Interactions in the Chiral Recognition Process through Functional Polymer Design

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