Polymorphisms in Isoniazid and Prothionamide Resistance Genes of the Mycobacterium tuberculosis Complex

M. Projahn; C. U. Koser; S. Homolka; D. K. Summers; John A.C. Archer; S. Niemann

doi:10.1128/AAC.00555-11

Polymorphisms in Isoniazid and Prothionamide Resistance Genes of the Mycobacterium tuberculosis Complex

M. Projahn, C. U. Koser, S. Homolka, D. K. Summers, John A.C. Archer, S. Niemann

Computer, Electrical and Mathematical Sciences and Engineering

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Sequence analyses of 74 strains that encompassed major phylogenetic lineages of the Mycobacterium tuberculosis complex revealed 10 polymorphisms in mshA (Rv0486) and four polymorphisms in inhA (Rv1484) that were not responsible for isoniazid or prothionamide resistance. Instead, some of these mutations were phylogenetically informative. This genetic diversity must be taken into consideration for drug development and for the design of molecular tests for drug resistance.

Original language	English (US)
Pages (from-to)	4408-4411
Number of pages	4
Journal	Antimicrobial Agents and Chemotherapy
Volume	55
Issue number	9
DOIs	https://doi.org/10.1128/AAC.00555-11
State	Published - Jun 27 2011

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10.1128/AAC.00555-11

https://repository.kaust.edu.sa/bitstream/10754/554098/1/Antimicrob.%20Agents%20Chemother.-2011-Projahn-4408-11.pdf

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title = "Polymorphisms in Isoniazid and Prothionamide Resistance Genes of the Mycobacterium tuberculosis Complex",

abstract = "Sequence analyses of 74 strains that encompassed major phylogenetic lineages of the Mycobacterium tuberculosis complex revealed 10 polymorphisms in mshA (Rv0486) and four polymorphisms in inhA (Rv1484) that were not responsible for isoniazid or prothionamide resistance. Instead, some of these mutations were phylogenetically informative. This genetic diversity must be taken into consideration for drug development and for the design of molecular tests for drug resistance.",

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AU - Projahn, M.

AU - Koser, C. U.

AU - Homolka, S.

AU - Summers, D. K.

AU - Archer, John A.C.

AU - Niemann, S.

N1 - KAUST Repository Item: Exported on 2020-10-01

PY - 2011/6/27

Y1 - 2011/6/27

N2 - Sequence analyses of 74 strains that encompassed major phylogenetic lineages of the Mycobacterium tuberculosis complex revealed 10 polymorphisms in mshA (Rv0486) and four polymorphisms in inhA (Rv1484) that were not responsible for isoniazid or prothionamide resistance. Instead, some of these mutations were phylogenetically informative. This genetic diversity must be taken into consideration for drug development and for the design of molecular tests for drug resistance.

AB - Sequence analyses of 74 strains that encompassed major phylogenetic lineages of the Mycobacterium tuberculosis complex revealed 10 polymorphisms in mshA (Rv0486) and four polymorphisms in inhA (Rv1484) that were not responsible for isoniazid or prothionamide resistance. Instead, some of these mutations were phylogenetically informative. This genetic diversity must be taken into consideration for drug development and for the design of molecular tests for drug resistance.

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VL - 55

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EP - 4411

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 9

ER -

Polymorphisms in Isoniazid and Prothionamide Resistance Genes of the Mycobacterium tuberculosis Complex

Abstract

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