@inproceedings{755a922165eb46a6b3c6f2be19d89840,
title = "Population analysis of the cingulum bundle using the tubular surface model for schizophrenia detection",
abstract = "We propose a novel framework for population analysis of DW-MRI data using the Tubular Surface Model. We focus on the Cingulum Bundle (CB)-a major tract for the Limbic System and the main connection of the Cingulate Gyrus, which has been associated with several aspects of Schizophrenia symptomatology. The Tubular Surface Model represents a tubular surface as a center-line with an associated radius function. It provides a natural way to sample statistics along the length of the fiber bundle and reduces the registration of fiber bundle surfaces to that of 4D curves. We apply our framework to a population of 20 subjects (10 normal, 10 schizophrenic) and obtain excellent results with neural network based classification (90% sensitivity, 95% specificity) as well as unsupervised clustering (k-means). Further, we apply statistical analysis to the feature data and characterize the discrimination ability of local regions of the CB, as a step towards localizing CB regions most relevant to Schizophrenia.",
author = "Vandana Mohan and Ganesh Sundaramoorthi and Marek Kubicki and Douglas Terry and Allen Tannenbaum",
note = "Publisher Copyright: {\textcopyright} 2016 SPIE.; Medical Imaging 2010: Computer-Aided Diagnosis ; Conference date: 16-02-2010 Through 18-02-2010",
year = "2010",
doi = "10.1117/12.844297",
language = "English (US)",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Summers, {Ronald M.} and Nico Karssemeijer",
booktitle = "Medical Imaging 2010",
}