Post-Translational Modification, Phase Separation, and Robust Gene Transcription

Hari R. Singh; Yogesh B. Ostwal

doi:10.1016/j.tig.2018.11.002

Post-Translational Modification, Phase Separation, and Robust Gene Transcription

Hari R. Singh, Yogesh B. Ostwal

King Abdullah University of Science and Technology

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

A few recent reports reveal fundamental new insights into the intricate regulatory mechanisms that govern RNA polymerase II (Pol II)-mediated gene transcription. Whereas a histidine-rich domain (HRD) triggers phase separation, promoting transcription elongation, a phosphatase switch promotes transcription termination. A paradigm that might govern the underlying mechanisms leading to robust gene transcription is now starting to emerge.

Original language	English (US)
Pages (from-to)	89-92
Number of pages	4
Journal	Trends in Genetics
Volume	35
Issue number	2
DOIs	https://doi.org/10.1016/j.tig.2018.11.002
State	Published - Nov 23 2018

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10.1016/j.tig.2018.11.002

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abstract = "A few recent reports reveal fundamental new insights into the intricate regulatory mechanisms that govern RNA polymerase II (Pol II)-mediated gene transcription. Whereas a histidine-rich domain (HRD) triggers phase separation, promoting transcription elongation, a phosphatase switch promotes transcription termination. A paradigm that might govern the underlying mechanisms leading to robust gene transcription is now starting to emerge.",

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Post-Translational Modification, Phase Separation, and Robust Gene Transcription

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