Prevention and treatment of hepatitis B recurrence after liver transplantation

Xiang Liang Zhang, Xiao Feng Zhu, Hui Juan Shi, Shu Zhong Cui, Yun Qiang Tang, Ming Chen Ba, Jia Kang Wang, Bin Wang, Qin Lu, Hong Yu Zhao, Yin Bing Wu, Mei Lu Li

    Research output: Contribution to journalArticlepeer-review

    1 Scopus citations


    Objective: To investigate the effect of the regimen of lamivudine (LAM) combined with hepatitis B immunoglobulin (HBIG) in prevention and treatment of re-infection of hepatitis B virus (HBV) and recurrence of hepatitis B after orthotopic liver transplantation (OLT) for HBV related end stage liver disease. Methods: The clinical data of 183 adult liver transplantation patients who lived more than 6 months and were followed up for 14.6 months with complete data were studied retrospectively. According to the HBV prevention strategy, these recipients were divided into two groups: group of pure LAM (n = 106) and group of LAM plus intramuscular injection of low dose HBIG (n = 77). Results: The rate of HBsAg negative conversion 1 week after OLT of the LAM group was 82.10% (87/106), significantly lower than that of the LAM + HBIG group [94.81% (73/77), P = 0.010]. The rates of HBV reinfection, HB recurrence, and YMDD mutation of the lamivudine group were 16.98% (18/ 106), 11.32% (12/106),and 8.49% (9/106) respectively, all significantly higher than those of the LAM + HBIG group [6.49% (5/77), 2.60% (2/77), and 1.30% (1/77) respectively, P = 0.035, 0.028, and 0.035 respectively]. All the patients with YMDD mutation were treated with adefovir (ADF) with improvement. Analysis showed no obvious difference in the effect of LAM given intramuscularly or intravenously. Conclusion: The protocol of combination of LAM and HBIG is highly effective, safe, and cost-effective in preventing the recurrence of HBV after OLT. YMDD mutation can be treated by ADF with satisfactory results.
    Original languageEnglish (US)
    Pages (from-to)606-609
    Number of pages4
    JournalNational Medical Journal of China
    Issue number9
    StatePublished - Mar 4 2008

    ASJC Scopus subject areas

    • General Medicine


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