Primary peptide folding dynamics observed with ultrafast temperature jump

Omar F. Mohammed; Gouri S. Jas; Milo M. Lin; Ahmed H. Zewail

doi:10.1002/anie.200900513

Primary peptide folding dynamics observed with ultrafast temperature jump

Omar F. Mohammed, Gouri S. Jas, Milo M. Lin, Ahmed H. Zewail

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

Fastest folding: An ultrafast laser temperature jump (T-jump) induces folding and unfolding of Wh5 (see picture), the shortest possible α-helical peptide. Using time-resolved fluorescence spectroscopy, the folding time of this peptide was found to span from less than one nanosecond to a few nanoseconds, redefining the meaning of ultrafast dynamics in protein and peptide folding.

Original language	English (US)
Pages (from-to)	5628-5632
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	48
Issue number	31
DOIs	https://doi.org/10.1002/anie.200900513
State	Published - Jul 20 2009
Externally published	Yes

Keywords

Helix-coil transitions
Peptide folding
Protein dynamics
Time-resolved spectroscopy

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/anie.200900513

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abstract = "Fastest folding: An ultrafast laser temperature jump (T-jump) induces folding and unfolding of Wh5 (see picture), the shortest possible α-helical peptide. Using time-resolved fluorescence spectroscopy, the folding time of this peptide was found to span from less than one nanosecond to a few nanoseconds, redefining the meaning of ultrafast dynamics in protein and peptide folding.",

keywords = "Helix-coil transitions, Peptide folding, Protein dynamics, Time-resolved spectroscopy",

author = "Mohammed, {Omar F.} and Jas, {Gouri S.} and Lin, {Milo M.} and Zewail, {Ahmed H.}",

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AU - Jas, Gouri S.

AU - Lin, Milo M.

AU - Zewail, Ahmed H.

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AB - Fastest folding: An ultrafast laser temperature jump (T-jump) induces folding and unfolding of Wh5 (see picture), the shortest possible α-helical peptide. Using time-resolved fluorescence spectroscopy, the folding time of this peptide was found to span from less than one nanosecond to a few nanoseconds, redefining the meaning of ultrafast dynamics in protein and peptide folding.

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KW - Peptide folding

KW - Protein dynamics

KW - Time-resolved spectroscopy

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Primary peptide folding dynamics observed with ultrafast temperature jump

Abstract

Keywords

ASJC Scopus subject areas

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