TY - JOUR
T1 - Proteome-Wide Chromatin Interactomics to Study Plant Epigenetics.
AU - Chen, Yanmei
AU - Liu, Peng
N1 - KAUST Repository Item: Exported on 2021-06-10
Acknowledgements: The work was supported by grants from National Natural Science Foundation of China (31470345 to Y.C.). The authors have no interests to declare.
PY - 2021/5/12
Y1 - 2021/5/12
N2 - Over 1000 proteins interact with and regulate plant chromatin, but the functions of most of these proteins are unclear. Advances in quantitative mass spectrometry (MS), interactomic mapping, and machine learning applications for data analysis have enabled proteome-wide investigations of chromatin regulation and in vivo studies of chromatin-bound protein functions and complex formation. Characterizing the protein-centric chromatin interactome would provide clues to how chromatin regulates epigenome landscapes and transcriptional programs related to diverse environmental and developmental cues.
AB - Over 1000 proteins interact with and regulate plant chromatin, but the functions of most of these proteins are unclear. Advances in quantitative mass spectrometry (MS), interactomic mapping, and machine learning applications for data analysis have enabled proteome-wide investigations of chromatin regulation and in vivo studies of chromatin-bound protein functions and complex formation. Characterizing the protein-centric chromatin interactome would provide clues to how chromatin regulates epigenome landscapes and transcriptional programs related to diverse environmental and developmental cues.
UR - http://hdl.handle.net/10754/669488
UR - https://linkinghub.elsevier.com/retrieve/pii/S1360138521000935
UR - http://www.scopus.com/inward/record.url?scp=85105518540&partnerID=8YFLogxK
U2 - 10.1016/j.tplants.2021.04.002
DO - 10.1016/j.tplants.2021.04.002
M3 - Article
C2 - 33975751
SN - 1360-1385
JO - Trends in Plant Science
JF - Trends in Plant Science
ER -