Proteomic profiling of the brain of mice with experimental cerebral malaria

Ehab Moussa, Honglei Huang, Malika Ahras, Amar Lall, Marie L. Thezenas, Roman Fischer, Benedikt M. Kessler, Arnab Pain, Oliver Billker, Climent Casals-Pascual

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Cerebral malaria (CM) is a severe neurological complication of malaria infection in both adults and children. In pursuit of effective treatment of CM, clinical studies, postmortem analysis and animal models have been employed to understand the pathology and identify effective interventions. In this study, a shotgun proteomics analysis was conducted to profile the proteomic signature of the brain tissue of mice with experimental cerebral malaria (ECM) in order to further understand the underlying pathology. To identify CM-associated response, proteomic signatures of the brains of C57/Bl6N mice infected with P. berghei ANKA that developed neurological syndrome were compared to those of mice infected with P. berghei NK65 that developed equally high parasite burdens without neurological signs, and to those of non-infected mice. The results show that the CM-associated response in mice that developed neurological signs comprise mainly acute-phase reaction and coagulation cascade activation, and indicate the leakage of plasma proteins into the brain parenchyma
Original languageEnglish (US)
Pages (from-to)61-69
Number of pages9
JournalJournal of Proteomics
Volume180
DOIs
StatePublished - May 8 2018

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