TY - JOUR
T1 - Quinone-fused porphyrins as contrast agents for photoacoustic imaging
AU - Banala, Srinivas
AU - Fokong, Stanley
AU - Brand, Christian
AU - Andreou, Chrysafis
AU - Kräutler, Bernhard
AU - Rueping, Magnus
AU - Kiessling, Fabian
N1 - KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: Financial support from the Excellence Initiative of the German federal and state governments through the I3TM Seed Fund Program and technical support from Fujifilm Visualsonics Inc (Drs Jithin Jose and Katrin Suppelt) are acknowledged. The authors particularly thank Drs Thomas Reiner, Jan Grimm and Moritz Kircher for their helpful discussions and support.
PY - 2017
Y1 - 2017
N2 - Photoacoustic (PA) imaging is an emerging non-invasive diagnostic modality with many potential clinical applications in oncology, rheumatology and the cardiovascular field. For this purpose, there is a high demand for exogenous contrast agents with high absorption coefficients in the optical window for tissue imaging, i.e. the near infrared (NIR) range between 680 and 950 nm. We herein report the photoacoustic properties of quinone-fused porphyrins inserted with different transition metals as new highly promising candidates. These dyes exhibit intense NIR absorption, a lack of fluorescence emission, and PA sensitivity in concentrations below 3 nmol mL. In this context, the highest PA signal was obtained with a Zn(ii) inserted dye. Furthermore, this dye was stable in blood serum and free thiol solution and exhibited negligible cell toxicity. Additionally, the Zn(ii) probe could be detected with an up to 3.2 fold higher PA intensity compared to the clinically most commonly used PA agent, ICG. Thus, further exploration of the 'quinone-fusing' approach to other chromophores may be an efficient way to generate highly potent PA agents that do not fluoresce and shift their absorption into the NIR range.
AB - Photoacoustic (PA) imaging is an emerging non-invasive diagnostic modality with many potential clinical applications in oncology, rheumatology and the cardiovascular field. For this purpose, there is a high demand for exogenous contrast agents with high absorption coefficients in the optical window for tissue imaging, i.e. the near infrared (NIR) range between 680 and 950 nm. We herein report the photoacoustic properties of quinone-fused porphyrins inserted with different transition metals as new highly promising candidates. These dyes exhibit intense NIR absorption, a lack of fluorescence emission, and PA sensitivity in concentrations below 3 nmol mL. In this context, the highest PA signal was obtained with a Zn(ii) inserted dye. Furthermore, this dye was stable in blood serum and free thiol solution and exhibited negligible cell toxicity. Additionally, the Zn(ii) probe could be detected with an up to 3.2 fold higher PA intensity compared to the clinically most commonly used PA agent, ICG. Thus, further exploration of the 'quinone-fusing' approach to other chromophores may be an efficient way to generate highly potent PA agents that do not fluoresce and shift their absorption into the NIR range.
UR - http://hdl.handle.net/10754/625873
UR - http://pubs.rsc.org/en/Content/ArticleLanding/2017/SC/C7SC01369H#!divAbstract
UR - http://www.scopus.com/inward/record.url?scp=85027835812&partnerID=8YFLogxK
U2 - 10.1039/c7sc01369h
DO - 10.1039/c7sc01369h
M3 - Article
C2 - 28989649
SN - 2041-6520
VL - 8
SP - 6176
EP - 6181
JO - Chem. Sci.
JF - Chem. Sci.
IS - 9
ER -