Régénération cellulaire neuronale post-ischémique: Potentiel thérapeutique

J. Badaut; L. Hirt; L. Regli; J. G. Villemure; J. Bogousslavsky; P. J. Magistretti

Régénération cellulaire neuronale post-ischémique: Potentiel thérapeutique

Translated title of the contribution: Post-ischemic neuronal regeneration: A potential for therapy

J. Badaut^*, L. Hirt, L. Regli, J. G. Villemure, J. Bogousslavsky, P. J. Magistretti

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

Several recent studies have demonstrated that pluri-potent progenitor cells (stem cells) are present and divide in the central nervous system in adult life. This neurogenesis occurs in specific areas of the brain, and can be enhanced by learning, but also by cerebral lesions. Cerebral ischemia for instance has been shown to increase neurogenesis. Furthermore, newly formed neurons seem to be able to replace the injured neurons functionally. These results are encouraging, and although a more refined understanding of the system is required, a therapeutical use of progenitor cells in the case of neuronal loss in neurodegenerative diseases, traumatic brain injury and cerebral ischemia can be envisioned in the future.

Translated title of the contribution	Post-ischemic neuronal regeneration: A potential for therapy
Original language	French
Pages (from-to)	2032-2037
Number of pages	6
Journal	Medecine et Hygiene
Volume	58
Issue number	2318
State	Published - Oct 18 2000
Externally published	Yes

ASJC Scopus subject areas

General Medicine

Cite this

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title = "R{\'e}g{\'e}n{\'e}ration cellulaire neuronale post-isch{\'e}mique: Potentiel th{\'e}rapeutique",

abstract = "Several recent studies have demonstrated that pluri-potent progenitor cells (stem cells) are present and divide in the central nervous system in adult life. This neurogenesis occurs in specific areas of the brain, and can be enhanced by learning, but also by cerebral lesions. Cerebral ischemia for instance has been shown to increase neurogenesis. Furthermore, newly formed neurons seem to be able to replace the injured neurons functionally. These results are encouraging, and although a more refined understanding of the system is required, a therapeutical use of progenitor cells in the case of neuronal loss in neurodegenerative diseases, traumatic brain injury and cerebral ischemia can be envisioned in the future.",

author = "J. Badaut and L. Hirt and L. Regli and Villemure, {J. G.} and J. Bogousslavsky and Magistretti, {P. J.}",

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TY - JOUR

T1 - Régénération cellulaire neuronale post-ischémique

T2 - Potentiel thérapeutique

AU - Badaut, J.

AU - Hirt, L.

AU - Regli, L.

AU - Villemure, J. G.

AU - Bogousslavsky, J.

AU - Magistretti, P. J.

PY - 2000/10/18

Y1 - 2000/10/18

N2 - Several recent studies have demonstrated that pluri-potent progenitor cells (stem cells) are present and divide in the central nervous system in adult life. This neurogenesis occurs in specific areas of the brain, and can be enhanced by learning, but also by cerebral lesions. Cerebral ischemia for instance has been shown to increase neurogenesis. Furthermore, newly formed neurons seem to be able to replace the injured neurons functionally. These results are encouraging, and although a more refined understanding of the system is required, a therapeutical use of progenitor cells in the case of neuronal loss in neurodegenerative diseases, traumatic brain injury and cerebral ischemia can be envisioned in the future.

AB - Several recent studies have demonstrated that pluri-potent progenitor cells (stem cells) are present and divide in the central nervous system in adult life. This neurogenesis occurs in specific areas of the brain, and can be enhanced by learning, but also by cerebral lesions. Cerebral ischemia for instance has been shown to increase neurogenesis. Furthermore, newly formed neurons seem to be able to replace the injured neurons functionally. These results are encouraging, and although a more refined understanding of the system is required, a therapeutical use of progenitor cells in the case of neuronal loss in neurodegenerative diseases, traumatic brain injury and cerebral ischemia can be envisioned in the future.

UR - http://www.scopus.com/inward/record.url?scp=0041160644&partnerID=8YFLogxK

M3 - Review article

AN - SCOPUS:0041160644

SN - 0025-6749

VL - 58

SP - 2032

EP - 2037

JO - Medecine et Hygiene

JF - Medecine et Hygiene

IS - 2318

ER -

Régénération cellulaire neuronale post-ischémique: Potentiel thérapeutique

Abstract

ASJC Scopus subject areas

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