Racial differences in markers of mineral metabolism in advanced chronic kidney disease

Anna Jovanovich, Michel Chonchol, Alfred K. Cheung, James S. Kaufman, Tom Greene, William L. Roberts, Gerard Smits, Jessica Kendrick

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Background and objectives This study examined differences in the concentration of markers of mineral metabolism across race in patients with advanced CKD not requiring dialysis and ESRD. Design, setting, participants, & measurements Concentrations of 25-hydroxyvitamin D (25(OH)D), 1,25-dihydroxyvitamin D (1,25(OH) 2D), intact parathyroid hormone (iPTH), and fibroblast growth factor 23 (FGF-23) were measured in stored plasma samples of 1497 patients with advanced CKD not yet on dialysis and ESRD who participated in the Homocysteine in Kidney and End Stage Renal Disease study. Linear regression models were used to examine the relationship between race and 25(OH)D, 1,25(OH) 2D, iPTH, and FGF-23 concentrations. Results Non-Hispanic white patients comprised 58% of the cohort, whereas non-Hispanic blacks comprised 42%. Median (interquartile range) FGF-23 concentrations were lower in blacks compared with whites with CKD (323 [181-655] versus 431 [232-1026] RU/ml; P
Original languageEnglish (US)
Pages (from-to)640-647
Number of pages8
JournalClinical Journal of the American Society of Nephrology
Volume7
Issue number4
DOIs
StatePublished - Apr 1 2012
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine
  • Critical Care and Intensive Care Medicine
  • Epidemiology
  • Nephrology
  • Transplantation

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