TY - JOUR
T1 - Racial differences in markers of mineral metabolism in advanced chronic kidney disease
AU - Jovanovich, Anna
AU - Chonchol, Michel
AU - Cheung, Alfred K.
AU - Kaufman, James S.
AU - Greene, Tom
AU - Roberts, William L.
AU - Smits, Gerard
AU - Kendrick, Jessica
N1 - Generated from Scopus record by KAUST IRTS on 2023-09-20
PY - 2012/4/1
Y1 - 2012/4/1
N2 - Background and objectives This study examined differences in the concentration of markers of mineral metabolism across race in patients with advanced CKD not requiring dialysis and ESRD. Design, setting, participants, & measurements Concentrations of 25-hydroxyvitamin D (25(OH)D), 1,25-dihydroxyvitamin D (1,25(OH) 2D), intact parathyroid hormone (iPTH), and fibroblast growth factor 23 (FGF-23) were measured in stored plasma samples of 1497 patients with advanced CKD not yet on dialysis and ESRD who participated in the Homocysteine in Kidney and End Stage Renal Disease study. Linear regression models were used to examine the relationship between race and 25(OH)D, 1,25(OH) 2D, iPTH, and FGF-23 concentrations. Results Non-Hispanic white patients comprised 58% of the cohort, whereas non-Hispanic blacks comprised 42%. Median (interquartile range) FGF-23 concentrations were lower in blacks compared with whites with CKD (323 [181-655] versus 431 [232-1026] RU/ml; P
AB - Background and objectives This study examined differences in the concentration of markers of mineral metabolism across race in patients with advanced CKD not requiring dialysis and ESRD. Design, setting, participants, & measurements Concentrations of 25-hydroxyvitamin D (25(OH)D), 1,25-dihydroxyvitamin D (1,25(OH) 2D), intact parathyroid hormone (iPTH), and fibroblast growth factor 23 (FGF-23) were measured in stored plasma samples of 1497 patients with advanced CKD not yet on dialysis and ESRD who participated in the Homocysteine in Kidney and End Stage Renal Disease study. Linear regression models were used to examine the relationship between race and 25(OH)D, 1,25(OH) 2D, iPTH, and FGF-23 concentrations. Results Non-Hispanic white patients comprised 58% of the cohort, whereas non-Hispanic blacks comprised 42%. Median (interquartile range) FGF-23 concentrations were lower in blacks compared with whites with CKD (323 [181-655] versus 431 [232-1026] RU/ml; P
UR - https://journals.lww.com/01277230-201204000-00018
UR - http://www.scopus.com/inward/record.url?scp=84859554593&partnerID=8YFLogxK
U2 - 10.2215/CJN.07020711
DO - 10.2215/CJN.07020711
M3 - Article
SN - 1555-9041
VL - 7
SP - 640
EP - 647
JO - Clinical Journal of the American Society of Nephrology
JF - Clinical Journal of the American Society of Nephrology
IS - 4
ER -