Rapid, efficient synthesis of heterobifunctional biodegradable dendrimers

Andrew P. Goodwin; Stephanie S. Lam; Jean M.J. Fréchet

doi:10.1021/ja071530z

Rapid, efficient synthesis of heterobifunctional biodegradable dendrimers

Andrew P. Goodwin, Stephanie S. Lam, Jean M.J. Fréchet^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

113 Scopus citations

Abstract

A method for the preparation of heterobifunctional biodegradable dendrimers is described involving the preparation of a symmetric aliphatic ester dendrimer derived from 2,2-bis(hydroxymethyl)propanoic acid bearing a cyclic carbonate periphery, followed by opening of the carbonate moieties with a functional amine. This approach requiring no chromatographic purification steps was demonstrated with the preparation of a dendrimer bearing eight protected aldehydes and eight alkynes at its periphery.

Original language	English (US)
Pages (from-to)	6994-6995
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	129
Issue number	22
DOIs	https://doi.org/10.1021/ja071530z
State	Published - Jun 6 2007
Externally published	Yes

ASJC Scopus subject areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja071530z

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abstract = "A method for the preparation of heterobifunctional biodegradable dendrimers is described involving the preparation of a symmetric aliphatic ester dendrimer derived from 2,2-bis(hydroxymethyl)propanoic acid bearing a cyclic carbonate periphery, followed by opening of the carbonate moieties with a functional amine. This approach requiring no chromatographic purification steps was demonstrated with the preparation of a dendrimer bearing eight protected aldehydes and eight alkynes at its periphery.",

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N2 - A method for the preparation of heterobifunctional biodegradable dendrimers is described involving the preparation of a symmetric aliphatic ester dendrimer derived from 2,2-bis(hydroxymethyl)propanoic acid bearing a cyclic carbonate periphery, followed by opening of the carbonate moieties with a functional amine. This approach requiring no chromatographic purification steps was demonstrated with the preparation of a dendrimer bearing eight protected aldehydes and eight alkynes at its periphery.

AB - A method for the preparation of heterobifunctional biodegradable dendrimers is described involving the preparation of a symmetric aliphatic ester dendrimer derived from 2,2-bis(hydroxymethyl)propanoic acid bearing a cyclic carbonate periphery, followed by opening of the carbonate moieties with a functional amine. This approach requiring no chromatographic purification steps was demonstrated with the preparation of a dendrimer bearing eight protected aldehydes and eight alkynes at its periphery.

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Rapid, efficient synthesis of heterobifunctional biodegradable dendrimers

Abstract

ASJC Scopus subject areas

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