Reactivity in Nickel Catalyzed Multicomponent Sequential Reductive Cross-Coupling Reactions

Haifeng Chen, Huifeng Yue, Chen Zhu, Magnus Rueping

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


A nickel-catalyzed three-component reductive carbonylation of alkyl halides, aryl halides, and ethyl chloroformate is described. Ethyl chloroformate is utilized as a safe and readily available source of CO in this multi-component protocol, providing an efficient and practical alternative for the synthesis of aryl-alkyl ketones. The reaction exhibits a wide substrate scope and good functional group compatibility. Experimental and DFT mechanistic studies highlight the complexity the cross-electrophile coupling and provide insight into the sequence of the three consecutive oxidative additions of aryl halide, chloroformate and akyl halide.
Original languageEnglish (US)
JournalAngewandte Chemie International Edition
StatePublished - Jun 21 2022

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis


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