TY - JOUR
T1 - Real-Time Dual-Wavelength Time-Resolved Diffuse Optical Tomography System for Functional Brain Imaging Based on Probe-Hosted Silicon Photomultipliers.
AU - Orive-Miguel, David
AU - Di Sieno, Laura
AU - Behera, Anurag
AU - Ferocino, Edoardo
AU - Contini, Davide
AU - Condat, Laurent
AU - Hervé, Lionel
AU - Mars, Jérôme
AU - Torricelli, Alessandro
AU - Pifferi, Antonio
AU - Dalla Mora, Alberto
N1 - KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: This research has received funding from the European Union’s Horizon 2020 Marie Skodowska-Curie Innovative Training Networks (ITN-ETN) programme, under Grant Agreement No. 675332 BitMap.
PY - 2020/5/21
Y1 - 2020/5/21
N2 - Near-infrared diffuse optical tomography is a non-invasive photonics-based imaging technology suited to functional brain imaging applications. Recent developments have proved that it is possible to build a compact time-domain diffuse optical tomography system based on silicon photomultipliers (SiPM) detectors. The system presented in this paper was equipped with the same eight SiPM probe-hosted detectors, but was upgraded with six injection fibers to shine the sample at several points. Moreover, an automatic switch was included enabling a complete measurement to be performed in less than one second. Further, the system was provided with a dual-wavelength ( 670 n m and 820 n m ) light source to quantify the oxy- and deoxy-hemoglobin concentration evolution in the tissue. This novel system was challenged against a solid phantom experiment, and two in-vivo tests, namely arm occlusion and motor cortex brain activation. The results show that the tomographic system makes it possible to follow the evolution of brain activation over time with a 1 s -resolution.
AB - Near-infrared diffuse optical tomography is a non-invasive photonics-based imaging technology suited to functional brain imaging applications. Recent developments have proved that it is possible to build a compact time-domain diffuse optical tomography system based on silicon photomultipliers (SiPM) detectors. The system presented in this paper was equipped with the same eight SiPM probe-hosted detectors, but was upgraded with six injection fibers to shine the sample at several points. Moreover, an automatic switch was included enabling a complete measurement to be performed in less than one second. Further, the system was provided with a dual-wavelength ( 670 n m and 820 n m ) light source to quantify the oxy- and deoxy-hemoglobin concentration evolution in the tissue. This novel system was challenged against a solid phantom experiment, and two in-vivo tests, namely arm occlusion and motor cortex brain activation. The results show that the tomographic system makes it possible to follow the evolution of brain activation over time with a 1 s -resolution.
UR - http://hdl.handle.net/10754/662935
UR - https://www.mdpi.com/1424-8220/20/10/2815
UR - http://www.scopus.com/inward/record.url?scp=85084964279&partnerID=8YFLogxK
U2 - 10.3390/s20102815
DO - 10.3390/s20102815
M3 - Article
C2 - 32429158
SN - 1424-8220
VL - 20
SP - 2815
JO - Sensors (Basel, Switzerland)
JF - Sensors (Basel, Switzerland)
IS - 10
ER -