TY - JOUR
T1 - Recent advances in aerosolised drug delivery
AU - Chandel, Akshay
AU - Goyal, Amit K.
AU - Ghosh, Goutam
AU - Rath, Goutam
N1 - Generated from Scopus record by KAUST IRTS on 2023-10-12
PY - 2019/4/1
Y1 - 2019/4/1
N2 - Pulmonary route is extensively studied for the diagnosis and treatment of pulmonary and extra pulmonary disease conditions such as asthma, tuberculosis, emphysema, and bronchitis. Formulation design, inhalation device and particle size play key role in determining the aerosol performance. The lack of desired clinical outcome along with the problem regarding efficacy or any adverse drug effect may arise due to improper training and education in use of the device to control the actuation and aerosol inhalation. This review summarizes the difference in the mechanistic features of current marketed aerosol delivery devices with respect to mechanism of aerosol generation with possible advancements in the aerosol design. The delivery options in the pulmonary route and its merits together with the limitations are also discussed. An update is provided regarding the current research and clinical outcome of the use of inhalational technology.
AB - Pulmonary route is extensively studied for the diagnosis and treatment of pulmonary and extra pulmonary disease conditions such as asthma, tuberculosis, emphysema, and bronchitis. Formulation design, inhalation device and particle size play key role in determining the aerosol performance. The lack of desired clinical outcome along with the problem regarding efficacy or any adverse drug effect may arise due to improper training and education in use of the device to control the actuation and aerosol inhalation. This review summarizes the difference in the mechanistic features of current marketed aerosol delivery devices with respect to mechanism of aerosol generation with possible advancements in the aerosol design. The delivery options in the pulmonary route and its merits together with the limitations are also discussed. An update is provided regarding the current research and clinical outcome of the use of inhalational technology.
UR - https://linkinghub.elsevier.com/retrieve/pii/S0753332218350066
UR - http://www.scopus.com/inward/record.url?scp=85061604091&partnerID=8YFLogxK
U2 - 10.1016/j.biopha.2019.108601
DO - 10.1016/j.biopha.2019.108601
M3 - Article
SN - 1950-6007
VL - 112
JO - Biomedicine and Pharmacotherapy
JF - Biomedicine and Pharmacotherapy
ER -
