Refillable and magnetically actuated drug delivery system using pear-shaped viscoelastic membrane

Hongyun So; Young Ho Seo; Albert P. Pisano

doi:10.1063/1.4893912

Refillable and magnetically actuated drug delivery system using pear-shaped viscoelastic membrane

Hongyun So, Young Ho Seo, Albert P. Pisano

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

We report a refillable and valveless drug delivery device actuated by an external magnetic field for on-demand drug release to treat localized diseases. The device features a pear-shaped viscoelastic magnetic membrane inducing asymmetrical deflection and consecutive touchdown motion to the bottom of the dome-shaped drug reservoir in response to a magnetic field, thus achieving controlled discharge of the drug. Maximum drug release with 18 ± 1.5 μg per actuation was achieved under a 500 mT magnetic flux density, and various controlled drug doses were investigated with the combination of the number of accumulated actuations and the strength of the magnetic field.

Original language	English (US)
Pages (from-to)	044119
Journal	Biomicrofluidics
Volume	8
Issue number	4
DOIs	https://doi.org/10.1063/1.4893912
State	Published - Jul 2014
Externally published	Yes

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10.1063/1.4893912

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title = "Refillable and magnetically actuated drug delivery system using pear-shaped viscoelastic membrane",

abstract = "We report a refillable and valveless drug delivery device actuated by an external magnetic field for on-demand drug release to treat localized diseases. The device features a pear-shaped viscoelastic magnetic membrane inducing asymmetrical deflection and consecutive touchdown motion to the bottom of the dome-shaped drug reservoir in response to a magnetic field, thus achieving controlled discharge of the drug. Maximum drug release with 18 ± 1.5 μg per actuation was achieved under a 500 mT magnetic flux density, and various controlled drug doses were investigated with the combination of the number of accumulated actuations and the strength of the magnetic field.",

author = "Hongyun So and Seo, {Young Ho} and Pisano, {Albert P.}",

note = "KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: This work was supported by the KAUST Global Collaborative Research grant under the Academic Excellence Alliance program. The authors also thank the UC Berkeley Marvell Nanolab and Biomolecular Nanotechnology Center where all devices were fabricated. This publication acknowledges KAUST support, but has no KAUST affiliated authors.",

year = "2014",

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doi = "10.1063/1.4893912",

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T1 - Refillable and magnetically actuated drug delivery system using pear-shaped viscoelastic membrane

AU - So, Hongyun

AU - Seo, Young Ho

AU - Pisano, Albert P.

N1 - KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: This work was supported by the KAUST Global Collaborative Research grant under the Academic Excellence Alliance program. The authors also thank the UC Berkeley Marvell Nanolab and Biomolecular Nanotechnology Center where all devices were fabricated. This publication acknowledges KAUST support, but has no KAUST affiliated authors.

PY - 2014/7

Y1 - 2014/7

N2 - We report a refillable and valveless drug delivery device actuated by an external magnetic field for on-demand drug release to treat localized diseases. The device features a pear-shaped viscoelastic magnetic membrane inducing asymmetrical deflection and consecutive touchdown motion to the bottom of the dome-shaped drug reservoir in response to a magnetic field, thus achieving controlled discharge of the drug. Maximum drug release with 18 ± 1.5 μg per actuation was achieved under a 500 mT magnetic flux density, and various controlled drug doses were investigated with the combination of the number of accumulated actuations and the strength of the magnetic field.

AB - We report a refillable and valveless drug delivery device actuated by an external magnetic field for on-demand drug release to treat localized diseases. The device features a pear-shaped viscoelastic magnetic membrane inducing asymmetrical deflection and consecutive touchdown motion to the bottom of the dome-shaped drug reservoir in response to a magnetic field, thus achieving controlled discharge of the drug. Maximum drug release with 18 ± 1.5 μg per actuation was achieved under a 500 mT magnetic flux density, and various controlled drug doses were investigated with the combination of the number of accumulated actuations and the strength of the magnetic field.

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DO - 10.1063/1.4893912

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JO - Biomicrofluidics

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ER -

Refillable and magnetically actuated drug delivery system using pear-shaped viscoelastic membrane

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