Regulation of Rhodopsin Phosphorylation by a Family of Neuronal Calcium Sensors

Edouard Decastro, Serge Nef, Hubert Fiumelli, Stefan E. Lenz, Satoru Kawamura, Patrick Nef*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

78 Scopus citations


Recoverin is a calcium sensor that regulates rhodopsin phosphorylation in a calcium-dependent manner. Cloning experiments indicate the presence of a numerous gene family, called the NCS family, encoding recoverin-like proteins expressed predominantly in neurons. Here, we report the cloning of three novel NCS genes, and demonstrate that at least six distinct members of the NCS family (including recoverin, S-modulin, vilip 1, NCS-1, Ce-NCS-1, and Ce-NCS-2) specifically inhibit rhodopsin phosphorylation. The presence of species homologues within the NCS family suggests that this function might be shared by at least 12 (out of 18) NCS proteins. Recent studies indicate that recoverin inhibits rhodopsin phosphorylation by directly regulating rhodopsin kinase, a G protein coupled receptor kinase (GRK). Since several NCS proteins are found in neurons throughout the entire nervous system, they may regulate other members of the GRK family. Together, our data suggest a general role for NCS proteins in the regulation of calcium-dependent phosphorylation in the nervous system.

Original languageEnglish (US)
Pages (from-to)133-140
Number of pages8
JournalBiochemical and Biophysical Research Communications
Issue number1
StatePublished - Jan 1 1995

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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