Relationship between intracortical electrode design and chronic recording function

Lohitash Karumbaiah, Tarun Saxena, David Carlson, Ketki Patil, Radhika Patkar, Eric A. Gaupp, Martha Betancur, Garrett B. Stanley, Lawrence Carin, Ravi V. Bellamkonda

Research output: Contribution to journalArticlepeer-review

181 Scopus citations


Intracortical electrodes record neural signals directly from local populations of neurons in the brain, and conduct them to external electronics that control prosthetics. However, the relationship between electrode design, defined by shape, size and tethering; and long-term (chronic) stability of the neuron-electrode interface is poorly understood. Here, we studied the effects of various commercially available intracortical electrode designs that vary in shape (cylindrical, planar), size (15μm, 50μm and 75μm), and tethering [electrode connections to connector with (tethered) and without tethering cable (untethered)] using histological, transcriptomic, and electrophysiological analyses over acute (3 day) and chronic (12 week) timepoints. Quantitative analysis of histological sections indicated that Michigan 50μm (M50) and Michigan tethered (MT) electrodes induced significantly (p
Original languageEnglish (US)
Pages (from-to)8061-8074
Number of pages14
Issue number33
StatePublished - Nov 1 2013
Externally publishedYes


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