Release of PLGA-encapsulated dexamethasone from microsphere loaded porous surfaces

G. J.S. Dawes, L. E. Fratila-Apachitei, B. S. Necula, I. Apachitei, G. J. Witkamp, J. Duszczyk

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


The aim of the present study was to investigate the morphology and function of a drug eluting metallic porous surface produced by the immobilization of poly lactide-co-glycolide microspheres bearing dexamethasone onto plasma electrolytically oxidized Ti-6Al-7Nb medical alloy. Spheres of 20 μm diameter were produced by an oil-in-water emulsion/solvent evaporation method and thermally immobilized onto titanium discs. The scanning electron microscopy investigations revealed that the size distribution and morphology of the attached spheres had not changed significantly. The drug release profiles following degradation in phosphate buffered saline for 1000 h showed that, upon immobilisation, the spheres maintained a sustained release, with a triphasic profile similar to the non-attached system. The only significant change was an increased release rate during the first 100 h. This difference was attributed to the effect of thermal attachment of the spheres to the surface.

Original languageEnglish (US)
Pages (from-to)215-221
Number of pages7
JournalJournal of Materials Science: Materials in Medicine
Issue number1
StatePublished - Jan 2010
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering


Dive into the research topics of 'Release of PLGA-encapsulated dexamethasone from microsphere loaded porous surfaces'. Together they form a unique fingerprint.

Cite this