Reprogramming toward heart regeneration: Stem cells and beyond

Aitor Aguirre; Ignacio Sancho-Martinez; Juan Carlos Izpisua Belmonte

doi:10.1016/j.stem.2013.02.008

Reprogramming toward heart regeneration: Stem cells and beyond

Aitor Aguirre, Ignacio Sancho-Martinez, Juan Carlos Izpisua Belmonte^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

56 Scopus citations

Abstract

Finding a cure for cardiovascular disease remains a major unmet medical need. Recent investigations have started to unveil the mechanisms of mammalian heart regeneration. The study of the regenerative mechanisms in lower vertebrate and mammalian animal models has provided clues for the experimental activation of proregenerative responses in the heart. In parallel, the use of endogenous adult stem cell populations alongside the recent application of reprogramming technologies has created major expectations for the development of therapies targeting heart disease. Together, these new approaches are bringing us closer to more successful strategies for the treatment of heart disease.

Original language	English (US)
Pages (from-to)	275-284
Number of pages	10
Journal	Cell Stem Cell
Volume	12
Issue number	3
DOIs	https://doi.org/10.1016/j.stem.2013.02.008
State	Published - Mar 7 2013
Externally published	Yes

ASJC Scopus subject areas

Molecular Medicine
Genetics
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.stem.2013.02.008

Cite this

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title = "Reprogramming toward heart regeneration: Stem cells and beyond",

abstract = "Finding a cure for cardiovascular disease remains a major unmet medical need. Recent investigations have started to unveil the mechanisms of mammalian heart regeneration. The study of the regenerative mechanisms in lower vertebrate and mammalian animal models has provided clues for the experimental activation of proregenerative responses in the heart. In parallel, the use of endogenous adult stem cell populations alongside the recent application of reprogramming technologies has created major expectations for the development of therapies targeting heart disease. Together, these new approaches are bringing us closer to more successful strategies for the treatment of heart disease.",

author = "Aitor Aguirre and Ignacio Sancho-Martinez and {Izpisua Belmonte}, {Juan Carlos}",

note = "Funding Information: We would first like to apologize to all those authors whose outstanding work could not be cited due to space constraints. We thank all members of the Izpisua Belmonte laboratory for critical discussion. I.S.-M. was partially supported by a Nomis Foundation Fellowship. Work in the laboratory of J.C.I.B. was supported by TERCEL-ISCIII-MINECO, CIBER, Fundacion Cellex, G. Harold and Leila Y. Mathers Charitable Foundation, and The Leona M. and Harry B. Helmsley Charitable Trust.",

year = "2013",

month = mar,

day = "7",

doi = "10.1016/j.stem.2013.02.008",

language = "English (US)",

volume = "12",

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journal = "Cell Stem Cell",

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T2 - Stem cells and beyond

AU - Aguirre, Aitor

AU - Sancho-Martinez, Ignacio

AU - Izpisua Belmonte, Juan Carlos

N1 - Funding Information: We would first like to apologize to all those authors whose outstanding work could not be cited due to space constraints. We thank all members of the Izpisua Belmonte laboratory for critical discussion. I.S.-M. was partially supported by a Nomis Foundation Fellowship. Work in the laboratory of J.C.I.B. was supported by TERCEL-ISCIII-MINECO, CIBER, Fundacion Cellex, G. Harold and Leila Y. Mathers Charitable Foundation, and The Leona M. and Harry B. Helmsley Charitable Trust.

PY - 2013/3/7

Y1 - 2013/3/7

N2 - Finding a cure for cardiovascular disease remains a major unmet medical need. Recent investigations have started to unveil the mechanisms of mammalian heart regeneration. The study of the regenerative mechanisms in lower vertebrate and mammalian animal models has provided clues for the experimental activation of proregenerative responses in the heart. In parallel, the use of endogenous adult stem cell populations alongside the recent application of reprogramming technologies has created major expectations for the development of therapies targeting heart disease. Together, these new approaches are bringing us closer to more successful strategies for the treatment of heart disease.

AB - Finding a cure for cardiovascular disease remains a major unmet medical need. Recent investigations have started to unveil the mechanisms of mammalian heart regeneration. The study of the regenerative mechanisms in lower vertebrate and mammalian animal models has provided clues for the experimental activation of proregenerative responses in the heart. In parallel, the use of endogenous adult stem cell populations alongside the recent application of reprogramming technologies has created major expectations for the development of therapies targeting heart disease. Together, these new approaches are bringing us closer to more successful strategies for the treatment of heart disease.

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U2 - 10.1016/j.stem.2013.02.008

DO - 10.1016/j.stem.2013.02.008

M3 - Review article

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EP - 284

JO - Cell Stem Cell

JF - Cell Stem Cell

IS - 3

ER -

Reprogramming toward heart regeneration: Stem cells and beyond

Abstract

ASJC Scopus subject areas

UN SDGs

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